2-((S)-2-tert-Butoxycarbonylamino-4-methylsulfanyl-butyryl)-pyrazolidine-1-carboxylic acid 4-nitro-phenyl ester

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Chemical Name:2-((S)-2-tert-Butoxycarbonylamino-4-methylsulfanyl-butyryl)-pyrazolidine-1-carboxylic acid 4-nitro-phenyl ester
CAS No.:186696-48-0
Molecular Formula:C₂₀H₂₈N₄O₇S
Molecular Weight:468.531
Hs Code.:

Synonyms:2-((S)-2-tert-Butoxycarbonylamino-4-methylsulfanyl-butyryl)-pyrazolidine-1-carboxylic acid 4-nitro-phenyl ester

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Chemical Property of 2-((S)-2-tert-Butoxycarbonylamino-4-methylsulfanyl-butyryl)-pyrazolidine-1-carboxylic acid 4-nitro-phenyl ester

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Technology Process of 2-((S)-2-tert-Butoxycarbonylamino-4-methylsulfanyl-butyryl)-pyrazolidine-1-carboxylic acid 4-nitro-phenyl ester

There total 3 articles about 2-((S)-2-tert-Butoxycarbonylamino-4-methylsulfanyl-butyryl)-pyrazolidine-1-carboxylic acid 4-nitro-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 7693-46-1
4-Nitrophenyl chloroformate

: 186696-47-9
[(S)-3-Methylsulfanyl-1-(pyrazolidine-1-carbonyl)-propyl]-carbamic acid tert-butyl ester

: 186696-48-0
2-((S)-2-tert-Butoxycarbonylamino-4-methylsulfanyl-butyryl)-pyrazolidine-1-carboxylic acid 4-nitro-phenyl ester

Guidance literature:: With TEA; In ethyl acetate; at 50 ℃; for 20h;
DOI:10.1002/ardp.19963291202

Reference yield:

: 2488-15-5
N-tert-butoxycarbonyl-L-methionine

: 186696-48-0
2-((S)-2-tert-Butoxycarbonylamino-4-methylsulfanyl-butyryl)-pyrazolidine-1-carboxylic acid 4-nitro-phenyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1) BOP-Cl, TEA, 2) TEA / 1) THF, 0 deg C, 5 min, 2) THF, DMF, 0 deg C, 1 h, r.t., overnight

2: 78 percent / 1,4-cyclohexadiene / 10percent Pd/C / ethanol / 1 h / 35 - 40 °C

3: 82 percent / TEA / ethyl acetate / 20 h / 50 °C

With cyclohexa-1,4-diene; TEA; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; palladium on activated charcoal; In ethanol; ethyl acetate;
DOI:10.1002/ardp.19963291202

Reference yield:

: 186696-46-8
2-((S)-2-tert-Butoxycarbonylamino-4-methylsulfanyl-butyryl)-pyrazolidine-1-carboxylic acid benzyl ester

: 186696-48-0
2-((S)-2-tert-Butoxycarbonylamino-4-methylsulfanyl-butyryl)-pyrazolidine-1-carboxylic acid 4-nitro-phenyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 78 percent / 1,4-cyclohexadiene / 10percent Pd/C / ethanol / 1 h / 35 - 40 °C

2: 82 percent / TEA / ethyl acetate / 20 h / 50 °C

With cyclohexa-1,4-diene; TEA; palladium on activated charcoal; In ethanol; ethyl acetate;
DOI:10.1002/ardp.19963291202