4-(4-acetaminophenyl)-6,7-dichloro-1-methyl-2-(pyrrolidine-1-carbonyl)-1,2-dihydrophthalazine

Base Information

Chemical Name:4-(4-acetaminophenyl)-6,7-dichloro-1-methyl-2-(pyrrolidine-1-carbonyl)-1,2-dihydrophthalazine
CAS No.:501107-01-3
Molecular Formula:C₂₂H₂₂Cl₂N₄O₂
Molecular Weight:445.348
Hs Code.:

Synonyms:4-(4-acetaminophenyl)-6,7-dichloro-1-methyl-2-(pyrrolidine-1-carbonyl)-1,2-dihydrophthalazine

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Chemical Property of 4-(4-acetaminophenyl)-6,7-dichloro-1-methyl-2-(pyrrolidine-1-carbonyl)-1,2-dihydrophthalazine

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Technology Process of 4-(4-acetaminophenyl)-6,7-dichloro-1-methyl-2-(pyrrolidine-1-carbonyl)-1,2-dihydrophthalazine

There total 9 articles about 4-(4-acetaminophenyl)-6,7-dichloro-1-methyl-2-(pyrrolidine-1-carbonyl)-1,2-dihydrophthalazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 123-75-1
pyrrolidine

: 280744-41-4
4-(4-acetaminophenyl)-6,7-dichloro-1-methyl-2-phenyloxycarbonyl-1,2-dihydrophthalazine

: 501107-01-3
4-(4-acetaminophenyl)-6,7-dichloro-1-methyl-2-(pyrrolidine-1-carbonyl)-1,2-dihydrophthalazine

Guidance literature:: In tetrahydrofuran; at 60 ℃; for 3h;
DOI:10.1002/jhet.5570390520

Reference yield:

: 95-75-0
3,4-Dichlorotoluene

: 501107-01-3
4-(4-acetaminophenyl)-6,7-dichloro-1-methyl-2-(pyrrolidine-1-carbonyl)-1,2-dihydrophthalazine

Guidance literature:: Multi-step reaction with 8 steps

1: 53 percent / aluminum chloride / 1,2-dichloro-ethane / 5 h / Heating

2: 42 percent / chromium(VI) oxide; concd. sulfuric acid / 4 h / 0 - 5 °C

3: 91 percent / hydrazine monohydrate / ethanol / 3 h / Heating

4: 85 percent / iron powd.; conc. hydrochloric acid / ethanol / 1 h / Heating

5: 84 percent / methanol / 4 h / Heating

6: 58 percent / tetrahydrofuran / 1 h / 0 °C

7: 62 percent / triethylamine / tetrahydrofuran / 1 h / 0 °C

8: 79 percent / tetrahydrofuran / 3 h / 60 °C

With chromium(VI) oxide; hydrogenchloride; aluminium trichloride; sulfuric acid; iron; hydrazine hydrate; triethylamine; In tetrahydrofuran; methanol; ethanol; 1,2-dichloro-ethane;
DOI:10.1002/jhet.5570390520

Reference yield:

: 122-04-3
4-nitro-benzoyl chloride

: 501107-01-3
4-(4-acetaminophenyl)-6,7-dichloro-1-methyl-2-(pyrrolidine-1-carbonyl)-1,2-dihydrophthalazine

Guidance literature:: Multi-step reaction with 8 steps

1: 53 percent / aluminum chloride / 1,2-dichloro-ethane / 5 h / Heating

2: 42 percent / chromium(VI) oxide; concd. sulfuric acid / 4 h / 0 - 5 °C

3: 91 percent / hydrazine monohydrate / ethanol / 3 h / Heating

4: 85 percent / iron powd.; conc. hydrochloric acid / ethanol / 1 h / Heating

5: 84 percent / methanol / 4 h / Heating

6: 58 percent / tetrahydrofuran / 1 h / 0 °C

7: 62 percent / triethylamine / tetrahydrofuran / 1 h / 0 °C

8: 79 percent / tetrahydrofuran / 3 h / 60 °C

With chromium(VI) oxide; hydrogenchloride; aluminium trichloride; sulfuric acid; iron; hydrazine hydrate; triethylamine; In tetrahydrofuran; methanol; ethanol; 1,2-dichloro-ethane;
DOI:10.1002/jhet.5570390520