rac-5-(3-bromophenyl)-2-fluoro-5-methyl-2-trifluoromethylmorpholin-3-thione

Base Information

Chemical Name:rac-5-(3-bromophenyl)-2-fluoro-5-methyl-2-trifluoromethylmorpholin-3-thione
CAS No.:1352419-13-6
Molecular Formula:C₁₂H₁₀BrF₄NOS
Molecular Weight:372.181
Hs Code.:

Synonyms:rac-5-(3-bromophenyl)-2-fluoro-5-methyl-2-trifluoromethylmorpholin-3-thione

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of rac-5-(3-bromophenyl)-2-fluoro-5-methyl-2-trifluoromethylmorpholin-3-thione

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Technology Process of rac-5-(3-bromophenyl)-2-fluoro-5-methyl-2-trifluoromethylmorpholin-3-thione

There total 7 articles about rac-5-(3-bromophenyl)-2-fluoro-5-methyl-2-trifluoromethylmorpholin-3-thione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1352419-12-5
rac-5-(3-bromophenyl)-2-fluoro-5-methyl-2-trifluoromethylmorpholin-3-one

: 1352419-13-6
rac-5-(3-bromophenyl)-2-fluoro-5-methyl-2-trifluoromethylmorpholin-3-thione

Guidance literature:: With Lawessons reagent; In toluene; at -78 - 20 ℃;

Reference yield:

: 953741-63-4
rac-2-amino-2-(3-bromo-phenyl)-propionitrile

: 1352419-13-6
rac-5-(3-bromophenyl)-2-fluoro-5-methyl-2-trifluoromethylmorpholin-3-thione

Guidance literature:: Multi-step reaction with 6 steps

1: hydrogenchloride / 96 h / Reflux

2: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / -15 - 0 °C

3: Chiralpak_.(R). Daicel / carbon dioxide; methanol / Resolution of racemate

4: di-isopropyl ether / 0 - 70 °C

5: diethylamino-sulfur trifluoride / dichloromethane / 0.5 h / 0 °C

6: Lawessons reagent / toluene / -78 - 20 °C

With Lawessons reagent; hydrogenchloride; lithium aluminium tetrahydride; diethylamino-sulfur trifluoride; In tetrahydrofuran; methanol; dichloromethane; di-isopropyl ether; carbon dioxide; toluene;

Reference yield:

: 2142-63-4
1-(3-Bromophenyl)ethanone

: 1352419-13-6
rac-5-(3-bromophenyl)-2-fluoro-5-methyl-2-trifluoromethylmorpholin-3-thione

Guidance literature:: Multi-step reaction with 7 steps

1: ammonium chloride / ammonia; methanol / 96 h / 20 °C

2: hydrogenchloride / 96 h / Reflux

3: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / -15 - 0 °C

4: Chiralpak_.(R). Daicel / carbon dioxide; methanol / Resolution of racemate

5: di-isopropyl ether / 0 - 70 °C

6: diethylamino-sulfur trifluoride / dichloromethane / 0.5 h / 0 °C

7: Lawessons reagent / toluene / -78 - 20 °C

With Lawessons reagent; hydrogenchloride; lithium aluminium tetrahydride; diethylamino-sulfur trifluoride; ammonium chloride; In tetrahydrofuran; methanol; dichloromethane; di-isopropyl ether; carbon dioxide; ammonia; toluene;