rac-5-(3-bromophenyl)-2-fluoro-5-methyl-2-trifluoromethylmorpholin-3-one

Base Information

Chemical Name:rac-5-(3-bromophenyl)-2-fluoro-5-methyl-2-trifluoromethylmorpholin-3-one
CAS No.:1352419-12-5
Molecular Formula:C₁₂H₁₀BrF₄NO₂
Molecular Weight:356.115
Hs Code.:

Synonyms:rac-5-(3-bromophenyl)-2-fluoro-5-methyl-2-trifluoromethylmorpholin-3-one

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Chemical Property of rac-5-(3-bromophenyl)-2-fluoro-5-methyl-2-trifluoromethylmorpholin-3-one

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Technology Process of rac-5-(3-bromophenyl)-2-fluoro-5-methyl-2-trifluoromethylmorpholin-3-one

There total 6 articles about rac-5-(3-bromophenyl)-2-fluoro-5-methyl-2-trifluoromethylmorpholin-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1352419-11-4
rac-5-(3-bromophenyl)-2-hydroxy-5-methyl-2-trifluoromethylmorpholin-3-one

: 1352419-12-5
rac-5-(3-bromophenyl)-2-fluoro-5-methyl-2-trifluoromethylmorpholin-3-one

Guidance literature:: rac-5-(3-bromophenyl)-2-hydroxy-5-methyl-2-trifluoromethylmorpholin-3-one; With diethylamino-sulfur trifluoride; In dichloromethane; at 0 ℃; for 0.5h;

With sodium hydrogencarbonate; In dichloromethane; water;

Reference yield:

: 2142-63-4
1-(3-Bromophenyl)ethanone

: 1352419-12-5
rac-5-(3-bromophenyl)-2-fluoro-5-methyl-2-trifluoromethylmorpholin-3-one

Guidance literature:: Multi-step reaction with 6 steps

1: ammonium chloride / ammonia; methanol / 96 h / 20 °C

2: hydrogenchloride / 96 h / Reflux

3: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / -15 - 0 °C

4: Chiralpak_.(R). Daicel / carbon dioxide; methanol / Resolution of racemate

5: di-isopropyl ether / 0 - 70 °C

6: diethylamino-sulfur trifluoride / dichloromethane / 0.5 h / 0 °C

With hydrogenchloride; lithium aluminium tetrahydride; diethylamino-sulfur trifluoride; ammonium chloride; In tetrahydrofuran; methanol; dichloromethane; di-isopropyl ether; carbon dioxide; ammonia;

Reference yield:

: 953741-63-4
rac-2-amino-2-(3-bromo-phenyl)-propionitrile

: 1352419-12-5
rac-5-(3-bromophenyl)-2-fluoro-5-methyl-2-trifluoromethylmorpholin-3-one

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogenchloride / 96 h / Reflux

2: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / -15 - 0 °C

3: Chiralpak_.(R). Daicel / carbon dioxide; methanol / Resolution of racemate

4: di-isopropyl ether / 0 - 70 °C

5: diethylamino-sulfur trifluoride / dichloromethane / 0.5 h / 0 °C

With hydrogenchloride; lithium aluminium tetrahydride; diethylamino-sulfur trifluoride; In tetrahydrofuran; methanol; dichloromethane; di-isopropyl ether; carbon dioxide;