(3S)-tert-butyl 3-(4-(2-(4-chlorobenzoyl)phenyl)-3-methylisoxazol-5-yl)-3-((R)-1,1-dimethylethylsulfinamido)propanoate

Base Information

Chemical Name:(3S)-tert-butyl 3-(4-(2-(4-chlorobenzoyl)phenyl)-3-methylisoxazol-5-yl)-3-((R)-1,1-dimethylethylsulfinamido)propanoate
CAS No.:1380089-42-8
Molecular Formula:C₂₈H₃₃ClN₂O₅S
Molecular Weight:545.099
Hs Code.:

Synonyms:(3S)-tert-butyl 3-(4-(2-(4-chlorobenzoyl)phenyl)-3-methylisoxazol-5-yl)-3-((R)-1,1-dimethylethylsulfinamido)propanoate

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Chemical Property of (3S)-tert-butyl 3-(4-(2-(4-chlorobenzoyl)phenyl)-3-methylisoxazol-5-yl)-3-((R)-1,1-dimethylethylsulfinamido)propanoate

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Technology Process of (3S)-tert-butyl 3-(4-(2-(4-chlorobenzoyl)phenyl)-3-methylisoxazol-5-yl)-3-((R)-1,1-dimethylethylsulfinamido)propanoate

There total 8 articles about (3S)-tert-butyl 3-(4-(2-(4-chlorobenzoyl)phenyl)-3-methylisoxazol-5-yl)-3-((R)-1,1-dimethylethylsulfinamido)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 321745-86-2
2-tert-butoxy-2-oxoethylzinc chloride

: 1380089-41-7
(R,E)-N-((4-(2-(4-chlorobenzoyl)phenyl)-3-methylisoxazol-5-yl)methylene)-2-methylpropan e-2-sulfinamide

: (3R)-tert-butyl 3-(4-(2-(4-chlorobenzoyl)phenyl)-3-methylisoxazol-5-yl)-3-((R)-1,1-dimethylethylsulfinamido)propanoate

: 1380089-42-8
(3S)-tert-butyl 3-(4-(2-(4-chlorobenzoyl)phenyl)-3-methylisoxazol-5-yl)-3-((R)-1,1-dimethylethylsulfinamido)propanoate

Guidance literature:: In tetrahydrofuran; at 0 ℃; for 1h;

Reference yield:

: 6630-33-7
ortho-bromobenzaldehyde

: (3R)-tert-butyl 3-(4-(2-(4-chlorobenzoyl)phenyl)-3-methylisoxazol-5-yl)-3-((R)-1,1-dimethylethylsulfinamido)propanoate

: 1380089-42-8
(3S)-tert-butyl 3-(4-(2-(4-chlorobenzoyl)phenyl)-3-methylisoxazol-5-yl)-3-((R)-1,1-dimethylethylsulfinamido)propanoate

Guidance literature:: Multi-step reaction with 7 steps

1: tetrahydrofuran / 0.5 h / 0 °C

2: triethylamine; oxalyl dichloride / dimethyl sulfoxide / dichloromethane / 0.5 h / -78 °C

3: potassium carbonate; water / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 110 °C / Inert atmosphere; Resealable vial

4: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 1 h / 0 °C

5: oxalyl dichloride / dimethyl sulfoxide / dichloromethane / 0.5 h / -78 °C

6: titanium(IV) tetraethanolate / tetrahydrofuran / 20 °C

7: tetrahydrofuran / 1 h / 0 °C

With oxalyl dichloride; lithium hydroxide monohydrate; water; potassium carbonate; triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; titanium(IV) tetraethanolate; dimethyl sulfoxide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane;

Reference yield:

: 873-77-8
(4-chlorphenyl)magnesium bromide

: (3R)-tert-butyl 3-(4-(2-(4-chlorobenzoyl)phenyl)-3-methylisoxazol-5-yl)-3-((R)-1,1-dimethylethylsulfinamido)propanoate

: 1380089-42-8
(3S)-tert-butyl 3-(4-(2-(4-chlorobenzoyl)phenyl)-3-methylisoxazol-5-yl)-3-((R)-1,1-dimethylethylsulfinamido)propanoate

Guidance literature:: Multi-step reaction with 7 steps

1: tetrahydrofuran / 0.5 h / 0 °C

2: triethylamine; oxalyl dichloride / dimethyl sulfoxide / dichloromethane / 0.5 h / -78 °C

3: potassium carbonate; water / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 110 °C / Inert atmosphere; Resealable vial

4: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 1 h / 0 °C

5: oxalyl dichloride / dimethyl sulfoxide / dichloromethane / 0.5 h / -78 °C

6: titanium(IV) tetraethanolate / tetrahydrofuran / 20 °C

7: tetrahydrofuran / 1 h / 0 °C

With oxalyl dichloride; lithium hydroxide monohydrate; water; potassium carbonate; triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; titanium(IV) tetraethanolate; dimethyl sulfoxide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane;