N-[3-(tert-butoxycarbonylamino)propyl]-N-cholesteryl-2-nitrobenzenesulfonamide

Base Information

Chemical Name:N-[3-(tert-butoxycarbonylamino)propyl]-N-cholesteryl-2-nitrobenzenesulfonamide
CAS No.:440358-97-4
Molecular Formula:C₄₁H₆₅N₃O₆S
Molecular Weight:728.05
Hs Code.:

Synonyms:N-[3-(tert-butoxycarbonylamino)propyl]-N-cholesteryl-2-nitrobenzenesulfonamide

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Chemical Property of N-[3-(tert-butoxycarbonylamino)propyl]-N-cholesteryl-2-nitrobenzenesulfonamide

Chemical Property:

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Technology Process of N-[3-(tert-butoxycarbonylamino)propyl]-N-cholesteryl-2-nitrobenzenesulfonamide

There total 4 articles about N-[3-(tert-butoxycarbonylamino)propyl]-N-cholesteryl-2-nitrobenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 116861-31-5
tert-butyl N-(3-chloropropyl)carbamate

: 390762-93-3
N-cholesteryl-2-nitrobenzenesulfonamide

: 440358-97-4
N-[3-(tert-butoxycarbonylamino)propyl]-N-cholesteryl-2-nitrobenzenesulfonamide

Guidance literature:: With potassium carbonate; In N,N-dimethyl acetamide; at 120 ℃; for 12h;
DOI:10.1021/ja0258733

Reference yield:

: 474-77-1
epicholesterol

: 440358-97-4
N-[3-(tert-butoxycarbonylamino)propyl]-N-cholesteryl-2-nitrobenzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: 64 percent / HN₃; PPh₃; diethylazodicarboxylate / benzene; toluene / 2 h / 23 °C

2: LiAlH₄ / diethyl ether / 2 h / 4 - 23 °C

3: 3.50 g / diisopropylethylamine / tetrahydrofuran / 2 h / 23 °C

4: 78 percent / K₂CO₃ / N,N-dimethyl-acetamide / 20 h / 120 °C

With lithium aluminium tetrahydride; tris-(2-chloro-ethyl)-amine; potassium carbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; diethyl ether; N,N-dimethyl acetamide; toluene; benzene; 1: Mitsunobu reaction;
DOI:10.1021/ja046663o

Reference yield:

: 601-54-7
Cholest-5-en-3-one

: 440358-97-4
N-[3-(tert-butoxycarbonylamino)propyl]-N-cholesteryl-2-nitrobenzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: 4.98 g / L-selectride / tetrahydrofuran / -78 - 23 °C

2: 64 percent / HN₃; PPh₃; diethylazodicarboxylate / benzene; toluene / 2 h / 23 °C

3: LiAlH₄ / diethyl ether / 2 h / 4 - 23 °C

4: 3.50 g / diisopropylethylamine / tetrahydrofuran / 2 h / 23 °C

5: 78 percent / K₂CO₃ / N,N-dimethyl-acetamide / 20 h / 120 °C

With lithium aluminium tetrahydride; tris-(2-chloro-ethyl)-amine; L-Selectride; potassium carbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; diethyl ether; N,N-dimethyl acetamide; toluene; benzene; 2: Mitsunobu reaction;
DOI:10.1021/ja046663o