(2,4-dimethyl-1-oxidopyridin-3-yl){4-methyl-4-[(3S)-3-methyl-4-{(1S)-1-[4-(trifluoromethyl)phenyl]ethyl}piperazin-1-yl]piperidin-1-yl}methanone

Base Information

Chemical Name:(2,4-dimethyl-1-oxidopyridin-3-yl){4-methyl-4-[(3S)-3-methyl-4-{(1S)-1-[4-(trifluoromethyl)phenyl]ethyl}piperazin-1-yl]piperidin-1-yl}methanone
CAS No.:306293-41-4
Molecular Formula:C₂₈H₃₇F₃N₄O₂
Molecular Weight:518.623
Hs Code.:
Mol file:306293-41-4.mol

(2,4-dimethyl-1-oxidopyridin-3-yl){4-methyl-4-[(3S)-3-methyl-4-{(1S)-1-[4-(trifluoromethyl)phenyl]ethyl}piperazin-1-yl]piperidin-1-yl}methanone

Synonyms:Piperidine,1-[(2,4-dimethyl-1-oxido-3-pyridinyl)carbonyl]-4-methyl-4-[(3S)-3-methyl-4-[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]-1-piperazinyl]-(9CI); Sch 350634

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Chemical Property of (2,4-dimethyl-1-oxidopyridin-3-yl){4-methyl-4-[(3S)-3-methyl-4-{(1S)-1-[4-(trifluoromethyl)phenyl]ethyl}piperazin-1-yl]piperidin-1-yl}methanone

Chemical Property:

Vapor Pressure:1.76E-16mmHg at 25°C
Boiling Point:644.1°C at 760 mmHg
Flash Point:343.3°C
Density:1.23g/cm³

Purity/Quality:

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Technology Process of (2,4-dimethyl-1-oxidopyridin-3-yl){4-methyl-4-[(3S)-3-methyl-4-{(1S)-1-[4-(trifluoromethyl)phenyl]ethyl}piperazin-1-yl]piperidin-1-yl}methanone

There total 21 articles about (2,4-dimethyl-1-oxidopyridin-3-yl){4-methyl-4-[(3S)-3-methyl-4-{(1S)-1-[4-(trifluoromethyl)phenyl]ethyl}piperazin-1-yl]piperidin-1-yl}methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1-oxido-2,4-dimethyl-pyridine-3-carboxylic acid

: 544704-12-3
2-methyl-4-(4-methylpiperidin-4-yl)-1-[1-(4-trifluoromethylphenyl)ethyl]piperazine

: 306293-41-4
Sch 350634

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 24h;
DOI:10.1021/jm0155401

Reference yield:

: 372156-99-5
3-carboxy-2,4-dimethylpyridine 1-oxide

: 544704-12-3
2-methyl-4-(4-methylpiperidin-4-yl)-1-[1-(4-trifluoromethylphenyl)ethyl]piperazine

: 306293-41-4
Sch 350634

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃;
DOI:10.1016/j.bmcl.2004.05.014

Reference yield:

: 709-63-7
1-(4-trifluoromethylphenyl)ethanone

: 306293-41-4
Sch 350634

Guidance literature:: Multi-step reaction with 7 steps

1: 54.2 percent / Et₃N; sodium triacetoxyborohydride; HOAc / 1,2-dichloro-ethane / 22 h / 20 °C

2: 96 percent / CH₂Cl₂ / 3 h / Heating

3: 80 percent / acetonitrile / Heating

4: 84 percent / 2-hydroxypyridine / toluene / 6 h / 90 °C

5: trifluoroacetic acid / CH₂Cl₂ / 20 °C

6: sodium borohydride; boron trifluoride etherate / 1,2-dimethoxy-ethane / Heating

7: 0.085 g / EDCI; HOBt; DIPEA / CH₂Cl₂ / 20 °C

With 2-hydroxypyridin; sodium tetrahydroborate; boron trifluoride diethyl etherate; sodium tris(acetoxy)borohydride; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In 1,2-dimethoxyethane; dichloromethane; 1,2-dichloro-ethane; toluene; acetonitrile;
DOI:10.1016/j.tet.2004.11.057