2-methyl-4-(4-methylpiperidin-4-yl)-1-[1-(4-trifluoromethylphenyl)ethyl]piperazine

Base Information

Chemical Name:2-methyl-4-(4-methylpiperidin-4-yl)-1-[1-(4-trifluoromethylphenyl)ethyl]piperazine
CAS No.:544704-12-3
Molecular Formula:C₂₀H₃₀F₃N₃
Molecular Weight:369.474
Hs Code.:

Synonyms:2-methyl-4-(4-methylpiperidin-4-yl)-1-[1-(4-trifluoromethylphenyl)ethyl]piperazine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-methyl-4-(4-methylpiperidin-4-yl)-1-[1-(4-trifluoromethylphenyl)ethyl]piperazine

Chemical Property:

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Technology Process of 2-methyl-4-(4-methylpiperidin-4-yl)-1-[1-(4-trifluoromethylphenyl)ethyl]piperazine

There total 20 articles about 2-methyl-4-(4-methylpiperidin-4-yl)-1-[1-(4-trifluoromethylphenyl)ethyl]piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 306297-00-7
tert-butyl 4-methyl-4-((S)-3-methyl-4-((S)-1-(4-(trifluoromethyl)phenyl)ethyl)piperazin-1-yl)piperidine-1-carboxylate

: 544704-12-3
2-methyl-4-(4-methylpiperidin-4-yl)-1-[1-(4-trifluoromethylphenyl)ethyl]piperazine

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 25 ℃; for 2h; basification;
DOI:10.1021/jm0155401

Reference yield:

: 709-63-7
1-(4-trifluoromethylphenyl)ethanone

: 544704-12-3
2-methyl-4-(4-methylpiperidin-4-yl)-1-[1-(4-trifluoromethylphenyl)ethyl]piperazine

Guidance literature:: Multi-step reaction with 6 steps

1: 54.2 percent / Et₃N; sodium triacetoxyborohydride; HOAc / 1,2-dichloro-ethane / 22 h / 20 °C

2: 96 percent / CH₂Cl₂ / 3 h / Heating

3: 80 percent / acetonitrile / Heating

4: 84 percent / 2-hydroxypyridine / toluene / 6 h / 90 °C

5: trifluoroacetic acid / CH₂Cl₂ / 20 °C

6: sodium borohydride; boron trifluoride etherate / 1,2-dimethoxy-ethane / Heating

With 2-hydroxypyridin; sodium tetrahydroborate; boron trifluoride diethyl etherate; sodium tris(acetoxy)borohydride; acetic acid; triethylamine; trifluoroacetic acid; In 1,2-dimethoxyethane; dichloromethane; 1,2-dichloro-ethane; toluene; acetonitrile;
DOI:10.1016/j.tet.2004.11.057