2-amino-6-chloro-9-[β-D-2’-deoxyribofuranosyl]-7-[(S)-1-(5-methoxy-2-nitrophenyl)-2,2-dimethylpropyloxy]methyl-7-deazapurine

Base Information

Chemical Name:2-amino-6-chloro-9-[β-D-2’-deoxyribofuranosyl]-7-[(S)-1-(5-methoxy-2-nitrophenyl)-2,2-dimethylpropyloxy]methyl-7-deazapurine
CAS No.:1372854-69-7
Molecular Formula:C₂₄H₃₀ClN₅O₇
Molecular Weight:535.985
Hs Code.:

Synonyms:2-amino-6-chloro-9-[β-D-2’-deoxyribofuranosyl]-7-[(S)-1-(5-methoxy-2-nitrophenyl)-2,2-dimethylpropyloxy]methyl-7-deazapurine

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Chemical Property of 2-amino-6-chloro-9-[β-D-2’-deoxyribofuranosyl]-7-[(S)-1-(5-methoxy-2-nitrophenyl)-2,2-dimethylpropyloxy]methyl-7-deazapurine

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Technology Process of 2-amino-6-chloro-9-[β-D-2’-deoxyribofuranosyl]-7-[(S)-1-(5-methoxy-2-nitrophenyl)-2,2-dimethylpropyloxy]methyl-7-deazapurine

There total 11 articles about 2-amino-6-chloro-9-[β-D-2’-deoxyribofuranosyl]-7-[(S)-1-(5-methoxy-2-nitrophenyl)-2,2-dimethylpropyloxy]methyl-7-deazapurine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₄₂H₇₂ClN₅O₇Si₃

: 1372854-69-7
2-amino-6-chloro-9-[β-D-2’-deoxyribofuranosyl]-7-[(S)-1-(5-methoxy-2-nitrophenyl)-2,2-dimethylpropyloxy]methyl-7-deazapurine

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 4h;
DOI:10.1002/anie.201106516

Reference yield:

: 1372854-35-7
(S)-1-(5-methoxy-2-nitrophenyl)-2,2-dimethyl-1-propyl (1S)-camphanate

: 1372854-69-7
2-amino-6-chloro-9-[β-D-2’-deoxyribofuranosyl]-7-[(S)-1-(5-methoxy-2-nitrophenyl)-2,2-dimethylpropyloxy]methyl-7-deazapurine

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / methanol / 1 h / Reflux

2: 0.75 h / 115 °C / Inert atmosphere

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 4 h / 20 °C

With tetrabutyl ammonium fluoride; potassium carbonate; In tetrahydrofuran; methanol;
DOI:10.1002/anie.201106516

Reference yield:

: 1372854-34-6
(R/S)-1-(5-methoxy-2-nitrophenyl)-2,2-dimethyl-1-propanol

: 1372854-69-7
2-amino-6-chloro-9-[β-D-2’-deoxyribofuranosyl]-7-[(S)-1-(5-methoxy-2-nitrophenyl)-2,2-dimethylpropyloxy]methyl-7-deazapurine

Guidance literature:: Multi-step reaction with 4 steps

1: dmap / dichloromethane / 20 °C / Inert atmosphere

2: potassium carbonate / methanol / 1 h / Reflux

3: 0.75 h / 115 °C / Inert atmosphere

4: tetrabutyl ammonium fluoride / tetrahydrofuran / 4 h / 20 °C

With dmap; tetrabutyl ammonium fluoride; potassium carbonate; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1002/anie.201106516