7-[(S)-1-(5-methoxy-2-nitrophenyl)-2,2-dimethylpropyloxy]methyl-7-deaza-2'-deoxyguanosine

Base Information

Chemical Name:7-[(S)-1-(5-methoxy-2-nitrophenyl)-2,2-dimethylpropyloxy]methyl-7-deaza-2'-deoxyguanosine
CAS No.:1372854-71-1
Molecular Formula:C₂₄H₃₁N₅O₈
Molecular Weight:517.539
Hs Code.:

Synonyms:7-[(S)-1-(5-methoxy-2-nitrophenyl)-2,2-dimethylpropyloxy]methyl-7-deaza-2'-deoxyguanosine

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Chemical Property of 7-[(S)-1-(5-methoxy-2-nitrophenyl)-2,2-dimethylpropyloxy]methyl-7-deaza-2'-deoxyguanosine

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Technology Process of 7-[(S)-1-(5-methoxy-2-nitrophenyl)-2,2-dimethylpropyloxy]methyl-7-deaza-2'-deoxyguanosine

There total 12 articles about 7-[(S)-1-(5-methoxy-2-nitrophenyl)-2,2-dimethylpropyloxy]methyl-7-deaza-2'-deoxyguanosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1372854-69-7
2-amino-6-chloro-9-[β-D-2’-deoxyribofuranosyl]-7-[(S)-1-(5-methoxy-2-nitrophenyl)-2,2-dimethylpropyloxy]methyl-7-deazapurine

: 1372854-71-1
7-[(S)-1-(5-methoxy-2-nitrophenyl)-2,2-dimethylpropyloxy]methyl-7-deaza-2'-deoxyguanosine

Guidance literature:: With 2-pyridinealdoxime; N,N,N',N'-tetramethylguanidine; In 1,4-dioxane; N,N-dimethyl-formamide; at 70 ℃; Inert atmosphere;
DOI:10.1002/anie.201106516

Reference yield:

: 1372854-34-6
(R/S)-1-(5-methoxy-2-nitrophenyl)-2,2-dimethyl-1-propanol

: 1372854-71-1
7-[(S)-1-(5-methoxy-2-nitrophenyl)-2,2-dimethylpropyloxy]methyl-7-deaza-2'-deoxyguanosine

Guidance literature:: Multi-step reaction with 5 steps

1: dmap / dichloromethane / 20 °C / Inert atmosphere

2: potassium carbonate / methanol / 1 h / Reflux

3: 0.75 h / 115 °C / Inert atmosphere

4: tetrabutyl ammonium fluoride / tetrahydrofuran / 4 h / 20 °C

5: 2-pyridinealdoxime; N,N,N',N'-tetramethylguanidine / 1,4-dioxane; N,N-dimethyl-formamide / 70 °C / Inert atmosphere

With 2-pyridinealdoxime; dmap; tetrabutyl ammonium fluoride; potassium carbonate; N,N,N',N'-tetramethylguanidine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/anie.201106516

Reference yield:

: 1372854-35-7
(S)-1-(5-methoxy-2-nitrophenyl)-2,2-dimethyl-1-propyl (1S)-camphanate

: 1372854-71-1
7-[(S)-1-(5-methoxy-2-nitrophenyl)-2,2-dimethylpropyloxy]methyl-7-deaza-2'-deoxyguanosine

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / methanol / 1 h / Reflux

2: 0.75 h / 115 °C / Inert atmosphere

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 4 h / 20 °C

4: 2-pyridinealdoxime; N,N,N',N'-tetramethylguanidine / 1,4-dioxane; N,N-dimethyl-formamide / 70 °C / Inert atmosphere

With 2-pyridinealdoxime; tetrabutyl ammonium fluoride; potassium carbonate; N,N,N',N'-tetramethylguanidine; In tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl-formamide;
DOI:10.1002/anie.201106516