5-hydroxy-7-[3-methoxy-4-(tetrahydropyran-2-yloxy)-phenyl]-4-{3-[3-methoxy-4-(tetrahydropyran-2-yloxy)-phenyl]-acryloyl}-hepta-2,4,6-trienoic acid ethyl ester

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Chemical Name:5-hydroxy-7-[3-methoxy-4-(tetrahydropyran-2-yloxy)-phenyl]-4-{3-[3-methoxy-4-(tetrahydropyran-2-yloxy)-phenyl]-acryloyl}-hepta-2,4,6-trienoic acid ethyl ester
CAS No.:884506-29-0
Molecular Formula:C₃₆H₄₂O₁₀
Molecular Weight:634.723
Hs Code.:

5-hydroxy-7-[3-methoxy-4-(tetrahydropyran-2-yloxy)-phenyl]-4-{3-[3-methoxy-4-(tetrahydropyran-2-yloxy)-phenyl]-acryloyl}-hepta-2,4,6-trienoic acid ethyl ester

Synonyms:5-hydroxy-7-[3-methoxy-4-(tetrahydropyran-2-yloxy)-phenyl]-4-{3-[3-methoxy-4-(tetrahydropyran-2-yloxy)-phenyl]-acryloyl}-hepta-2,4,6-trienoic acid ethyl ester

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Chemical Property of 5-hydroxy-7-[3-methoxy-4-(tetrahydropyran-2-yloxy)-phenyl]-4-{3-[3-methoxy-4-(tetrahydropyran-2-yloxy)-phenyl]-acryloyl}-hepta-2,4,6-trienoic acid ethyl ester

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Technology Process of 5-hydroxy-7-[3-methoxy-4-(tetrahydropyran-2-yloxy)-phenyl]-4-{3-[3-methoxy-4-(tetrahydropyran-2-yloxy)-phenyl]-acryloyl}-hepta-2,4,6-trienoic acid ethyl ester

There total 2 articles about 5-hydroxy-7-[3-methoxy-4-(tetrahydropyran-2-yloxy)-phenyl]-4-{3-[3-methoxy-4-(tetrahydropyran-2-yloxy)-phenyl]-acryloyl}-hepta-2,4,6-trienoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 884506-67-6
5-hydroxy-1,7-bis-[3-methoxy-4-(tetrahydropyran-2-yloxy)-phenyl]-hepta-1,4,6-trien-3-one

: 623-47-2
propynoic acid ethyl ester

: 884506-29-0
5-hydroxy-7-[3-methoxy-4-(tetrahydropyran-2-yloxy)-phenyl]-4-{3-[3-methoxy-4-(tetrahydropyran-2-yloxy)-phenyl]-acryloyl}-hepta-2,4,6-trienoic acid ethyl ester

Guidance literature:: 5-hydroxy-1,7-bis-[3-methoxy-4-(tetrahydropyran-2-yloxy)-phenyl]-hepta-1,4,6-trien-3-one; With sodium hydride; In tetrahydrofuran; at 0 - 20 ℃; for 2.5h;

propynoic acid ethyl ester; In tetrahydrofuran; at 20 ℃; for 2h;
DOI:10.1016/j.bmc.2005.11.034

Reference yield:

: 98885-93-9,115851-80-4,147556-16-9
curcumin

: 884506-29-0
5-hydroxy-7-[3-methoxy-4-(tetrahydropyran-2-yloxy)-phenyl]-4-{3-[3-methoxy-4-(tetrahydropyran-2-yloxy)-phenyl]-acryloyl}-hepta-2,4,6-trienoic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 66.8 percent / PPTS / CH₂Cl₂ / 48 h / 20 °C

2.1: sodium hydride / tetrahydrofuran / 2.5 h / 0 - 20 °C

2.2: 62 percent / tetrahydrofuran / 2 h / 20 °C

With pyridinium p-toluenesulfonate; sodium hydride; In tetrahydrofuran; dichloromethane; 2.2: Michael addition;
DOI:10.1016/j.bmc.2005.11.034