(2S,4R)-2-trifluoromethyl-4-phenyl-3-((2R)-3-(N,N-dibenzylamino)-2-benzylpropanoyl)oxazolidine

Base Information

Chemical Name:(2S,4R)-2-trifluoromethyl-4-phenyl-3-((2R)-3-(N,N-dibenzylamino)-2-benzylpropanoyl)oxazolidine
CAS No.:1026021-07-7
Molecular Formula:C₃₄H₃₃F₃N₂O₂
Molecular Weight:558.643
Hs Code.:

Synonyms:(2S,4R)-2-trifluoromethyl-4-phenyl-3-((2R)-3-(N,N-dibenzylamino)-2-benzylpropanoyl)oxazolidine

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Chemical Property of (2S,4R)-2-trifluoromethyl-4-phenyl-3-((2R)-3-(N,N-dibenzylamino)-2-benzylpropanoyl)oxazolidine

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Technology Process of (2S,4R)-2-trifluoromethyl-4-phenyl-3-((2R)-3-(N,N-dibenzylamino)-2-benzylpropanoyl)oxazolidine

There total 1 articles about (2S,4R)-2-trifluoromethyl-4-phenyl-3-((2R)-3-(N,N-dibenzylamino)-2-benzylpropanoyl)oxazolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1026021-04-4
(2S,4R)-2-trifluoromethyl-4-phenyl-3-(3-(N,N-dibenzylamino)propanoyl)oxazolidine

: 100-39-0
benzyl bromide

: 1026021-07-7
(2S,4R)-2-trifluoromethyl-4-phenyl-3-((2R)-3-(N,N-dibenzylamino)-2-benzylpropanoyl)oxazolidine

Guidance literature:: (2S,4R)-2-trifluoromethyl-4-phenyl-3-(3-(N,N-dibenzylamino)propanoyl)oxazolidine; With sodium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 1.5h;

benzyl bromide; In tetrahydrofuran; at -78 ℃; for 3h; Further stages.;
DOI:10.1021/jo800562x

Reference yield: 78.0%

: 1026021-07-7
(2S,4R)-2-trifluoromethyl-4-phenyl-3-((2R)-3-(N,N-dibenzylamino)-2-benzylpropanoyl)oxazolidine

: (2R)-3-(N,N-dibenzylamino)-2-benzylpropan-1-ol

: 203176-56-1
(2S,4R)-2-trifluoromethyl-4-phenyl-1,3-oxazolidine

Guidance literature:: (2S,4R)-2-trifluoromethyl-4-phenyl-3-((2R)-3-(N,N-dibenzylamino)-2-benzylpropanoyl)oxazolidine; With lithium aluminium tetrahydride; In diethyl ether; at -10 ℃; for 2.5h;

With sodium tetrahydroborate; In methanol; at 20 ℃; for 2h; Further stages.;
DOI:10.1021/jo800562x

Reference yield: 72.0%

: 1026021-07-7
(2S,4R)-2-trifluoromethyl-4-phenyl-3-((2R)-3-(N,N-dibenzylamino)-2-benzylpropanoyl)oxazolidine

: 1026021-15-7
(2R)-2-benzyl-3-(N,N-dibenzylamino)propanoic acid

: 203176-56-1
(2S,4R)-2-trifluoromethyl-4-phenyl-1,3-oxazolidine

Guidance literature:: (2S,4R)-2-trifluoromethyl-4-phenyl-3-((2R)-3-(N,N-dibenzylamino)-2-benzylpropanoyl)oxazolidine; With lithium aluminium tetrahydride; In diethyl ether; at -10 ℃; for 2.5h;

With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; In tetrahydrofuran; tert-butyl alcohol; at 20 ℃; for 1h; Further stages.;
DOI:10.1021/jo800562x