(2S,4R)-2-trifluoromethyl-4-phenyl-3-(3-(N,N-dibenzylamino)propanoyl)oxazolidine

Base Information

• Chemical Name: (2S,4R)-2-trifluoromethyl-4-phenyl-3-(3-(N,N-dibenzylamino)propanoyl)oxazolidine
• CAS No.: 1026021-04-4
• Molecular Formula: C₂₇H₂₇F₃N₂O₂
• Molecular Weight: 468.519
• Mol file: 1026021-04-4.mol

Synonyms:(2S,4R)-2-trifluoromethyl-4-phenyl-3-(3-(N,N-dibenzylamino)propanoyl)oxazolidine

Chemical Property of (2S,4R)-2-trifluoromethyl-4-phenyl-3-(3-(N,N-dibenzylamino)propanoyl)oxazolidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S,4R)-2-trifluoromethyl-4-phenyl-3-(3-(N,N-dibenzylamino)propanoyl)oxazolidine

There total 1 articles about (2S,4R)-2-trifluoromethyl-4-phenyl-3-(3-(N,N-dibenzylamino)propanoyl)oxazolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

(2S,4R)-2-trifluoromethyl-4-phenyl-3-propenoyloxazolidine (1026021-02-2) + dibenzylamine (103-49-1) → (2S,4R)-2-trifluoromethyl-4-phenyl-3-(3-(N,N-dibenzylamino)propanoyl)oxazolidine (1026021-04-4)

Guidance literature:

With triethylamine; at 50 ℃; for 30h;

DOI:10.1021/jo800562x

Reference yield: 86.0%

(2S,4R)-2-trifluoromethyl-4-phenyl-3-(3-(N,N-dibenzylamino)propanoyl)oxazolidine (1026021-04-4) + benzyl bromide (100-39-0) → (2S,4R)-2-trifluoromethyl-4-phenyl-3-((2R)-3-(N,N-dibenzylamino)-2-benzylpropanoyl)oxazolidine (1026021-07-7)

Guidance literature:

(2S,4R)-2-trifluoromethyl-4-phenyl-3-(3-(N,N-dibenzylamino)propanoyl)oxazolidine; With sodium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 1.5h;

benzyl bromide; In tetrahydrofuran; at -78 ℃; for 3h; Further stages.;

DOI:10.1021/jo800562x

Reference yield: 84.0%

(2S,4R)-2-trifluoromethyl-4-phenyl-3-(3-(N,N-dibenzylamino)propanoyl)oxazolidine (1026021-04-4) + methyl iodide (74-88-4) → (2S,4R)-2-trifluoromethyl-4-phenyl-3-((2R)-3-(N,N-dibenzylamino)-2-methylpropanoyl)oxazolidine (1026021-06-6)

Guidance literature:

(2S,4R)-2-trifluoromethyl-4-phenyl-3-(3-(N,N-dibenzylamino)propanoyl)oxazolidine; With sodium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 1.5h;

methyl iodide; In tetrahydrofuran; at -78 ℃; for 3h; Further stages.;

DOI:10.1021/jo800562x

upstream raw materials:

(2S,4R)-2-trifluoromethyl-4-phenyl-3-propenoyloxazolidine

dibenzylamine

Downstream raw materials:

(2S,4R)-2-trifluoromethyl-4-phenyl-3-((2R)-3-(N,N-dibenzylamino)-2-isobutylpropanoyl)oxazolidine

(2S,4R)-2-trifluoromethyl-4-phenyl-3-((2R)-3-(N,N-dibenzylamino)-2-benzylpropanoyl)oxazolidine

(2S,4R)-2-trifluoromethyl-4-phenyl-3-((2R)-3-(N,N-dibenzylamino)-2-ethylpropanoyl)oxazolidine

(2S,4R)-2-trifluoromethyl-4-phenyl-3-((2R)-3-(N,N-dibenzylamino)-2-allylpropanoyl)oxazolidine