1-(phenylsulfonyl)-7-hydroxy-3-methyl-4-nitro-5-indole

Base Information

Chemical Name:1-(phenylsulfonyl)-7-hydroxy-3-methyl-4-nitro-5-indole
CAS No.:116911-67-2
Molecular Formula:C₁₉H₁₉N₃O₇S₂
Molecular Weight:465.508
Hs Code.:

1-(phenylsulfonyl)-7-hydroxy-3-methyl-4-nitro-5-<N-(2-propenyl)methanesulfonamido>indole

Synonyms:1-(phenylsulfonyl)-7-hydroxy-3-methyl-4-nitro-5-indole

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(phenylsulfonyl)-7-hydroxy-3-methyl-4-nitro-5-indole

Chemical Property:

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Technology Process of 1-(phenylsulfonyl)-7-hydroxy-3-methyl-4-nitro-5-indole

There total 9 articles about 1-(phenylsulfonyl)-7-hydroxy-3-methyl-4-nitro-5-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 116911-65-0
1-(phenylsulfonyl)-7-(benzyloxy)-3-methyl-4-nitro-5-indole

: 116911-67-2
1-(phenylsulfonyl)-7-hydroxy-3-methyl-4-nitro-5-indole

Guidance literature:: With cyclohexane; boron tribromide; In dichloromethane; at -20 ℃; for 0.5h;
DOI:10.1021/jo00256a036

Reference yield:

: 25945-95-3
N-<2-(benzyloxy)-4-nitrophenyl>acetamide

: 116911-67-2
1-(phenylsulfonyl)-7-hydroxy-3-methyl-4-nitro-5-indole

Guidance literature:: Multi-step reaction with 8 steps

1: Zn, CaCl₂, ethanol / 1.5 h / Heating

2: 80 percent / pyridine / CH₂Cl₂ / 2 h / 25 °C

3: 80 percent / potessium tert-butoxide / dimethylformamide / 3 h / Ambient temperature

4: 82 percent / 50percent aq. KOH / ethanol / 8 h / Heating

5: 1.) NaNO₂, HCl, SnCl₂ / 1.) 2 h, 2.) RT, 12 h

6: 1.) NaH / 1.) THF, 0 deg C, 1 h, 2.)THF, RT, 8 h

7: ammonium nitrate, trifluoroacetic anhydride / CHCl₃ / 6 h

8: BBr₃, cyclohexane / CH₂Cl₂ / 0.5 h / -20 °C

With pyridine; hydrogenchloride; potassium hydroxide; ammonium nitrate; ethanol; cyclohexane; potassium tert-butylate; boron tribromide; sodium hydride; trifluoroacetic anhydride; calcium chloride; tin(ll) chloride; zinc; sodium nitrite; In ethanol; dichloromethane; chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jo00256a036

Reference yield:

: 25351-89-7
N-(2-hydroxy-4-nitrophenyl)acetamide

: 116911-67-2
1-(phenylsulfonyl)-7-hydroxy-3-methyl-4-nitro-5-indole

Guidance literature:: Multi-step reaction with 9 steps

1: 84 percent / KI, K₂CO₃ / dimethylformamide / 4 h

2: Zn, CaCl₂, ethanol / 1.5 h / Heating

3: 80 percent / pyridine / CH₂Cl₂ / 2 h / 25 °C

4: 80 percent / potessium tert-butoxide / dimethylformamide / 3 h / Ambient temperature

5: 82 percent / 50percent aq. KOH / ethanol / 8 h / Heating

6: 1.) NaNO₂, HCl, SnCl₂ / 1.) 2 h, 2.) RT, 12 h

7: 1.) NaH / 1.) THF, 0 deg C, 1 h, 2.)THF, RT, 8 h

8: ammonium nitrate, trifluoroacetic anhydride / CHCl₃ / 6 h

9: BBr₃, cyclohexane / CH₂Cl₂ / 0.5 h / -20 °C

With pyridine; hydrogenchloride; potassium hydroxide; ammonium nitrate; ethanol; cyclohexane; potassium tert-butylate; boron tribromide; sodium hydride; potassium carbonate; trifluoroacetic anhydride; potassium iodide; calcium chloride; tin(ll) chloride; zinc; sodium nitrite; In ethanol; dichloromethane; chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jo00256a036