(3R,6S,1'R,2'S,3'S)-3-[4-tert-butyldiphenylsilyloxy-1-hydroxy-2,3-isopropylidenedioxybutyl]-2,5-dimethoxy-3,6-dihydro-6-isopropylpyrazine

Base Information

Chemical Name:(3R,6S,1'R,2'S,3'S)-3-[4-tert-butyldiphenylsilyloxy-1-hydroxy-2,3-isopropylidenedioxybutyl]-2,5-dimethoxy-3,6-dihydro-6-isopropylpyrazine
CAS No.:1018061-95-4
Molecular Formula:C₃₂H₄₆N₂O₆Si
Molecular Weight:582.813
Hs Code.:

Synonyms:(3R,6S,1'R,2'S,3'S)-3-[4-tert-butyldiphenylsilyloxy-1-hydroxy-2,3-isopropylidenedioxybutyl]-2,5-dimethoxy-3,6-dihydro-6-isopropylpyrazine

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Chemical Property of (3R,6S,1'R,2'S,3'S)-3-[4-tert-butyldiphenylsilyloxy-1-hydroxy-2,3-isopropylidenedioxybutyl]-2,5-dimethoxy-3,6-dihydro-6-isopropylpyrazine

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Technology Process of (3R,6S,1'R,2'S,3'S)-3-[4-tert-butyldiphenylsilyloxy-1-hydroxy-2,3-isopropylidenedioxybutyl]-2,5-dimethoxy-3,6-dihydro-6-isopropylpyrazine

There total 2 articles about (3R,6S,1'R,2'S,3'S)-3-[4-tert-butyldiphenylsilyloxy-1-hydroxy-2,3-isopropylidenedioxybutyl]-2,5-dimethoxy-3,6-dihydro-6-isopropylpyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1018062-12-8
(3R,6S,1'R,2'S,3'S)-3-(1,4-dihydroxy-2,3-isopropylidenedioxybutyl)-2,5-dimethoxy-3,6-dihydro-6-isopropylpyrazine

: 58479-61-1
tert-butylchlorodiphenylsilane

: 1018061-95-4
(3R,6S,1'R,2'S,3'S)-3-[4-tert-butyldiphenylsilyloxy-1-hydroxy-2,3-isopropylidenedioxybutyl]-2,5-dimethoxy-3,6-dihydro-6-isopropylpyrazine

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 20 ℃; for 24h;
DOI:10.1021/jo702601z

Reference yield:

: 78342-42-4
(S)-2-isopropyl-3,6-dimethoxy-2,5-dihydropyrazine

: 101331-92-4
4-O-(tert-butyldiphenylsilyl)-2,3-O-isopropylidene-L-threose

: 1018061-95-4
(3R,6S,1'R,2'S,3'S)-3-[4-tert-butyldiphenylsilyloxy-1-hydroxy-2,3-isopropylidenedioxybutyl]-2,5-dimethoxy-3,6-dihydro-6-isopropylpyrazine

: 1018062-03-7
(3R,6S,1'S,2'S,3'S)-3-[4-tert-butyldiphenylsilyloxy-1-hydroxy-2,3-isopropylidenedioxybutyl]-2,5-dimethoxy-3,6-dihydro-6-isopropylpyrazine

: 3-[4-tert-butyldiphenylsilyloxy-1-hydroxy-2,3-isopropylidenedioxybutyl]-2,5-dimethoxy-3,6-dihydro-6-isopropylpyrazine

Guidance literature:: (S)-2-isopropyl-3,6-dimethoxy-2,5-dihydropyrazine; With n-butyllithium; tin(ll) chloride; In tetrahydrofuran; hexane; at -78 ℃; for 1h;

4-O-(tert-butyldiphenylsilyl)-2,3-O-isopropylidene-L-threose; In tetrahydrofuran; hexane; at -78 ℃; for 2h; Further stages.;
DOI:10.1021/jo702601z