threo-1-methyl-2-(trimethylsiloxy)cyclohexyl isocyanide

Base Information

• Chemical Name: threo-1-methyl-2-(trimethylsiloxy)cyclohexyl isocyanide
• CAS No.: 83152-88-9
• Molecular Formula: C₁₁H₂₁NOSi
• Molecular Weight: 211.379
• Mol file: 83152-88-9.mol

Synonyms:threo-1-methyl-2-(trimethylsiloxy)cyclohexyl isocyanide

Chemical Property of threo-1-methyl-2-(trimethylsiloxy)cyclohexyl isocyanide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of threo-1-methyl-2-(trimethylsiloxy)cyclohexyl isocyanide

There total 1 articles about threo-1-methyl-2-(trimethylsiloxy)cyclohexyl isocyanide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

1,2-epoxy-1-methylcyclohexane (1713-33-3) + trimethylsilyl cyanide (7677-24-9) → threo-1-methyl-2-(trimethylsiloxy)cyclohexyl isocyanide (83152-88-9)

Guidance literature:

With palladium(II) cyanide; In dichloromethane; for 2h; Heating;

DOI:10.1021/jo00382a008

Reference yield: 81.0%

threo-1-methyl-2-(trimethylsiloxy)cyclohexyl isocyanide (83152-88-9) → trans-2-isocyano-2-methylcyclohexanol (83152-89-0)

Guidance literature:

With potassium fluoride;

DOI:10.1021/ja00385a078

upstream raw materials:

1,2-epoxy-1-methylcyclohexane

trimethylsilyl cyanide

Downstream raw materials:

trans-2-isocyano-2-methylcyclohexanol

Refernces

• 1、 Imi, Katsuharu,Yanagihara, Naoto,Utimoto, Kiitiro. "Reaction of Cyanotrimethylsilane with Oxiranes. Effect of Catalysts or Mediators on Regioselectivity and Ambident Character". . p. 1013 - 1016. Retrieved 2007/10/02.