(Z)-1-phenyl-3-(triisopropylsilyl)prop-2-yn-1-one O-methyl oxime

Base Information

• Chemical Name: (Z)-1-phenyl-3-(triisopropylsilyl)prop-2-yn-1-one O-methyl oxime
• CAS No.: 870127-42-7
• Molecular Formula: C₁₉H₂₉NOSi
• Molecular Weight: 315.531
• Mol file: 870127-42-7.mol

Synonyms:(Z)-1-phenyl-3-(triisopropylsilyl)prop-2-yn-1-one O-methyl oxime

Chemical Property of (Z)-1-phenyl-3-(triisopropylsilyl)prop-2-yn-1-one O-methyl oxime

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (Z)-1-phenyl-3-(triisopropylsilyl)prop-2-yn-1-one O-methyl oxime

There total 3 articles about (Z)-1-phenyl-3-(triisopropylsilyl)prop-2-yn-1-one O-methyl oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

N-methoxylamine hydrochloride (593-56-6) + 3-(tri(isopropyl)silyl)-1-phenylprop-2-yn-1-one (503595-76-4) → (Z)-1-phenyl-3-(triisopropylsilyl)prop-2-yn-1-one O-methyl oxime (870127-42-7)

Guidance literature:

With pyridine; sodium sulfate; In methanol; at 20 ℃;

DOI:10.1021/ol052027z

Reference yield:

tris-iso-propylsilyl acetylene (89343-06-6) → (Z)-1-phenyl-3-(triisopropylsilyl)prop-2-yn-1-one O-methyl oxime (870127-42-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 82 percent / CuI; Et₃N / PdCl₂(PPh₃)2 / 20 °C

2: 82 percent / Na₂SO₄; pyridine / methanol / 20 °C

With pyridine; copper(l) iodide; sodium sulfate; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In methanol; 1: Sonogashira coupling reaction;

DOI:10.1021/ol052027z

Reference yield:

benzoyl chloride (98-88-4) → (Z)-1-phenyl-3-(triisopropylsilyl)prop-2-yn-1-one O-methyl oxime (870127-42-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 82 percent / CuI; Et₃N / PdCl₂(PPh₃)2 / 20 °C

2: 82 percent / Na₂SO₄; pyridine / methanol / 20 °C

With pyridine; copper(l) iodide; sodium sulfate; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In methanol; 1: Sonogashira coupling reaction;

DOI:10.1021/ol052027z

upstream raw materials:

N-methoxylamine hydrochloride

3-(tri(isopropyl)silyl)-1-phenylprop-2-yn-1-one

tris-iso-propylsilyl acetylene

benzoyl chloride