2-[2-(4-Cyclopropyl-phenyl)-1-oxo-2,8-diaza-spiro[4.5]dec-8-yl]-propionic acid

Base Information

Chemical Name:2-[2-(4-Cyclopropyl-phenyl)-1-oxo-2,8-diaza-spiro[4.5]dec-8-yl]-propionic acid
CAS No.:1309765-95-4
Molecular Formula:C₂₀H₂₆N₂O₃
Molecular Weight:342.438
Hs Code.:

Synonyms:2-[2-(4-Cyclopropyl-phenyl)-1-oxo-2,8-diaza-spiro[4.5]dec-8-yl]-propionic acid

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Chemical Property of 2-[2-(4-Cyclopropyl-phenyl)-1-oxo-2,8-diaza-spiro[4.5]dec-8-yl]-propionic acid

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Technology Process of 2-[2-(4-Cyclopropyl-phenyl)-1-oxo-2,8-diaza-spiro[4.5]dec-8-yl]-propionic acid

There total 3 articles about 2-[2-(4-Cyclopropyl-phenyl)-1-oxo-2,8-diaza-spiro[4.5]dec-8-yl]-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 19.0%

: 1255650-29-3
2-(4-Cyclopropyl-phenyl)-2,8-diaza-spiro[4.5]decan-1-one

: 598-72-1,10327-08-9
2-Bromopropionic acid

: 1309765-95-4
2-[2-(4-Cyclopropyl-phenyl)-1-oxo-2,8-diaza-spiro[4.5]dec-8-yl]-propionic acid

Guidance literature:: With triethylamine; In 1,2-dichloro-ethane; at 80 ℃; for 2h;

Reference yield:

: 1255644-43-9
4-(2-methoxy-ethyl)-piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester

: 1309765-95-4
2-[2-(4-Cyclopropyl-phenyl)-1-oxo-2,8-diaza-spiro[4.5]dec-8-yl]-propionic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: dimethylaluminum chloride / ethyl acetate; toluene; hexane; methanol / 15 h / 115 °C

1.2: pH 2

1.3: pH 8

2.1: triethylamine / 1,2-dichloro-ethane / 2 h / 80 °C

With dimethylaluminum chloride; triethylamine; In methanol; hexane; ethyl acetate; 1,2-dichloro-ethane; toluene;

Reference yield:

: 142851-03-4
1-tert-butyl 4-ethyl piperidine-1,4-dicarboxylate

: 1309765-95-4
2-[2-(4-Cyclopropyl-phenyl)-1-oxo-2,8-diaza-spiro[4.5]dec-8-yl]-propionic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 3 h / -5 °C

1.2: -5 - 20 °C

2.1: dimethylaluminum chloride / ethyl acetate; toluene; hexane; methanol / 15 h / 115 °C

2.2: pH 2

2.3: pH 8

3.1: triethylamine / 1,2-dichloro-ethane / 2 h / 80 °C

With dimethylaluminum chloride; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; methanol; hexane; ethyl acetate; 1,2-dichloro-ethane; toluene;