2-[(E)-(3R,9S,10R)-11-(tert-Butyl-diphenyl-silanyloxy)-3,10-dimethyl-4-methylene-9-(2-trimethylsilanyl-ethoxymethoxy)-undec-7-enyloxy]-tetrahydro-pyran

Base Information

Chemical Name:2-[(E)-(3R,9S,10R)-11-(tert-Butyl-diphenyl-silanyloxy)-3,10-dimethyl-4-methylene-9-(2-trimethylsilanyl-ethoxymethoxy)-undec-7-enyloxy]-tetrahydro-pyran
CAS No.:216494-32-5
Molecular Formula:C₄₁H₆₆O₅Si₂
Molecular Weight:695.143
Hs Code.:

2-[(E)-(3R,9S,10R)-11-(tert-Butyl-diphenyl-silanyloxy)-3,10-dimethyl-4-methylene-9-(2-trimethylsilanyl-ethoxymethoxy)-undec-7-enyloxy]-tetrahydro-pyran

Synonyms:2-[(E)-(3R,9S,10R)-11-(tert-Butyl-diphenyl-silanyloxy)-3,10-dimethyl-4-methylene-9-(2-trimethylsilanyl-ethoxymethoxy)-undec-7-enyloxy]-tetrahydro-pyran

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Chemical Property of 2-[(E)-(3R,9S,10R)-11-(tert-Butyl-diphenyl-silanyloxy)-3,10-dimethyl-4-methylene-9-(2-trimethylsilanyl-ethoxymethoxy)-undec-7-enyloxy]-tetrahydro-pyran

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Technology Process of 2-[(E)-(3R,9S,10R)-11-(tert-Butyl-diphenyl-silanyloxy)-3,10-dimethyl-4-methylene-9-(2-trimethylsilanyl-ethoxymethoxy)-undec-7-enyloxy]-tetrahydro-pyran

There total 6 articles about 2-[(E)-(3R,9S,10R)-11-(tert-Butyl-diphenyl-silanyloxy)-3,10-dimethyl-4-methylene-9-(2-trimethylsilanyl-ethoxymethoxy)-undec-7-enyloxy]-tetrahydro-pyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: C₁₃H₂₃ClO₂Zn

: 216494-30-3
C₂₈H₄₃IO₃Si₂

: 216494-32-5
2-[(E)-(3R,9S,10R)-11-(tert-Butyl-diphenyl-silanyloxy)-3,10-dimethyl-4-methylene-9-(2-trimethylsilanyl-ethoxymethoxy)-undec-7-enyloxy]-tetrahydro-pyran

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; at 22 ℃;
DOI:10.1021/ja982572d

Reference yield:

: 76513-69-4
(2-trimethylethylsilylethoxy)methyl chloride

: 216494-32-5
2-[(E)-(3R,9S,10R)-11-(tert-Butyl-diphenyl-silanyloxy)-3,10-dimethyl-4-methylene-9-(2-trimethylsilanyl-ethoxymethoxy)-undec-7-enyloxy]-tetrahydro-pyran

Guidance literature:: Multi-step reaction with 3 steps

1: iPr₂NEt, DMAP / CH₂Cl₂

2: 1.) Cp₂ZrHCl, 2.) NIS / 1.) CH₂Cl₂, 2.) CH₂Cl₂

3: 84 percent / (PPh₃)4Pd / 22 °C

With dmap; N-iodo-succinimide; Schwartz's reagent; tetrakis(triphenylphosphine) palladium⁽⁰⁾; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1021/ja982572d

Reference yield:

: 127665-69-4
((2R,3R)-3-((R)-1-((tert-butyldiphenylsilyl)oxy)propan-2-yl)oxiran-2-yl)methanol

: 216494-32-5
2-[(E)-(3R,9S,10R)-11-(tert-Butyl-diphenyl-silanyloxy)-3,10-dimethyl-4-methylene-9-(2-trimethylsilanyl-ethoxymethoxy)-undec-7-enyloxy]-tetrahydro-pyran

Guidance literature:: Multi-step reaction with 5 steps

1: NCS, Ph₃P / CH₂Cl₂ / Heating

2: LDA / tetrahydrofuran / -30 °C

3: iPr₂NEt, DMAP / CH₂Cl₂

4: 1.) Cp₂ZrHCl, 2.) NIS / 1.) CH₂Cl₂, 2.) CH₂Cl₂

5: 84 percent / (PPh₃)4Pd / 22 °C

With dmap; N-chloro-succinimide; N-iodo-succinimide; Schwartz's reagent; tetrakis(triphenylphosphine) palladium⁽⁰⁾; N-ethyl-N,N-diisopropylamine; triphenylphosphine; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja982572d