2-[[(3R,3aR,6S,6aS)-6-fluoro-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3-yl]oxy]-6-chloro-5-(4-phenylphenyl)-1H-imidazo[4,5-b]pyridine

Base Information

Chemical Name:2-[[(3R,3aR,6S,6aS)-6-fluoro-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3-yl]oxy]-6-chloro-5-(4-phenylphenyl)-1H-imidazo[4,5-b]pyridine
CAS No.:1394372-84-9
Molecular Formula:C₂₄H₁₉ClFN₃O₃
Molecular Weight:451.885
Hs Code.:

Synonyms:2-[[(3R,3aR,6S,6aS)-6-fluoro-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3-yl]oxy]-6-chloro-5-(4-phenylphenyl)-1H-imidazo[4,5-b]pyridine

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Chemical Property of 2-[[(3R,3aR,6S,6aS)-6-fluoro-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3-yl]oxy]-6-chloro-5-(4-phenylphenyl)-1H-imidazo[4,5-b]pyridine

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Technology Process of 2-[[(3R,3aR,6S,6aS)-6-fluoro-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3-yl]oxy]-6-chloro-5-(4-phenylphenyl)-1H-imidazo[4,5-b]pyridine

There total 10 articles about 2-[[(3R,3aR,6S,6aS)-6-fluoro-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3-yl]oxy]-6-chloro-5-(4-phenylphenyl)-1H-imidazo[4,5-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1394374-10-7
2-[[2-[[(3R,3aR,6S,6aS)-6-fluoro-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3-yl]oxy]-6-chloro-5-(4-phenylphenyl)imidazo[4,5-b]pyridin-1-yl]methoxy]ethyl-trimethyl-silane

: 1394372-84-9
2-[[(3R,3aR,6S,6aS)-6-fluoro-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3-yl]oxy]-6-chloro-5-(4-phenylphenyl)-1H-imidazo[4,5-b]pyridine

Guidance literature:: With potassium hydrogensulfate; formic acid; In water; at 40 ℃; for 4h;

Reference yield:

: 5409-39-2
2-amino-5-chloro-3-nitropyridine

: 1394372-84-9
2-[[(3R,3aR,6S,6aS)-6-fluoro-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3-yl]oxy]-6-chloro-5-(4-phenylphenyl)-1H-imidazo[4,5-b]pyridine

Guidance literature:: Multi-step reaction with 11 steps

1.1: N-chloro-succinimide; acetic acid / 80 °C

2.1: sodium iodide; acetic acid / 2 h / 90 °C

3.1: ethanol / tin(II) chloride hydrate / 0.5 h / 70 °C

4.1: dmap / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

5.1: potassium hydroxide / ethanol / 0.5 h / 20 °C

5.2: 1 h / 20 °C

6.1: Oxone / acetonitrile; water / 18 h / 20 °C

7.1: potassium phosphate / palladium diacetate; catacxium A / water; tetrahydrofuran / 42 h / 45 °C / Inert atmosphere

8.1: triethylamine / tetrahydrofuran / 0.25 h / 0 - 20 °C

9.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / ISOPROPYLAMIDE / 20 °C

10.1: diethylamino-sulfur trifluoride / dichloromethane / 21.5 h / 0 - 20 °C

11.1: formic acid; potassium hydrogensulfate / water / 4 h / 40 °C

With Oxone; potassium phosphate; potassium hydrogensulfate; N-chloro-succinimide; formic acid; ethanol; diethylamino-sulfur trifluoride; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; sodium iodide; potassium hydroxide; dmap; tin(II) chloride hydrate; palladium diacetate; catacxium A; In tetrahydrofuran; ethanol; dichloromethane; ISOPROPYLAMIDE; water; acetonitrile;

Reference yield:

: 203794-33-6
2-amino-5,6-dichloro-3-nitropyridine

: 1394372-84-9
2-[[(3R,3aR,6S,6aS)-6-fluoro-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3-yl]oxy]-6-chloro-5-(4-phenylphenyl)-1H-imidazo[4,5-b]pyridine

Guidance literature:: Multi-step reaction with 10 steps

1.1: sodium iodide; acetic acid / 2 h / 90 °C

2.1: ethanol / tin(II) chloride hydrate / 0.5 h / 70 °C

3.1: dmap / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

4.1: potassium hydroxide / ethanol / 0.5 h / 20 °C

4.2: 1 h / 20 °C

5.1: Oxone / acetonitrile; water / 18 h / 20 °C

6.1: potassium phosphate / palladium diacetate; catacxium A / water; tetrahydrofuran / 42 h / 45 °C / Inert atmosphere

7.1: triethylamine / tetrahydrofuran / 0.25 h / 0 - 20 °C

8.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / ISOPROPYLAMIDE / 20 °C

9.1: diethylamino-sulfur trifluoride / dichloromethane / 21.5 h / 0 - 20 °C

10.1: formic acid; potassium hydrogensulfate / water / 4 h / 40 °C

With Oxone; potassium phosphate; potassium hydrogensulfate; formic acid; ethanol; diethylamino-sulfur trifluoride; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; sodium iodide; potassium hydroxide; dmap; tin(II) chloride hydrate; palladium diacetate; catacxium A; In tetrahydrofuran; ethanol; dichloromethane; ISOPROPYLAMIDE; water; acetonitrile;