2-[[2-[[(3R,3aR,6S,6aS)-6-fluoro-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3-yl]oxy]-6-chloro-5-(4-phenylphenyl)imidazo[4,5-b]pyridin-1-yl]methoxy]ethyl-trimethyl-silane

Base Information

Chemical Name:2-[[2-[[(3R,3aR,6S,6aS)-6-fluoro-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3-yl]oxy]-6-chloro-5-(4-phenylphenyl)imidazo[4,5-b]pyridin-1-yl]methoxy]ethyl-trimethyl-silane
CAS No.:1394374-10-7
Molecular Formula:C₃₀H₃₃ClFN₃O₄Si
Molecular Weight:582.147
Hs Code.:

2-[[2-[[(3R,3aR,6S,6aS)-6-fluoro-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3-yl]oxy]-6-chloro-5-(4-phenylphenyl)imidazo[4,5-b]pyridin-1-yl]methoxy]ethyl-trimethyl-silane

Synonyms:2-[[2-[[(3R,3aR,6S,6aS)-6-fluoro-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3-yl]oxy]-6-chloro-5-(4-phenylphenyl)imidazo[4,5-b]pyridin-1-yl]methoxy]ethyl-trimethyl-silane

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Chemical Property of 2-[[2-[[(3R,3aR,6S,6aS)-6-fluoro-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3-yl]oxy]-6-chloro-5-(4-phenylphenyl)imidazo[4,5-b]pyridin-1-yl]methoxy]ethyl-trimethyl-silane

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Technology Process of 2-[[2-[[(3R,3aR,6S,6aS)-6-fluoro-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3-yl]oxy]-6-chloro-5-(4-phenylphenyl)imidazo[4,5-b]pyridin-1-yl]methoxy]ethyl-trimethyl-silane

There total 9 articles about 2-[[2-[[(3R,3aR,6S,6aS)-6-fluoro-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3-yl]oxy]-6-chloro-5-(4-phenylphenyl)imidazo[4,5-b]pyridin-1-yl]methoxy]ethyl-trimethyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1394373-59-1
(3R,3aR,6R,6aR)-6-[6-chloro-5-(4-phenylphenyl)-1-(2-trimethylsilylethoxymethyl)imidazo[4,5-b]pyridin-2-yl]oxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3-ol

: 1394374-10-7
2-[[2-[[(3R,3aR,6S,6aS)-6-fluoro-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3-yl]oxy]-6-chloro-5-(4-phenylphenyl)imidazo[4,5-b]pyridin-1-yl]methoxy]ethyl-trimethyl-silane

Guidance literature:: With diethylamino-sulfur trifluoride; In dichloromethane; at 0 - 20 ℃; for 21.5h;

Reference yield:

: 5409-39-2
2-amino-5-chloro-3-nitropyridine

: 1394374-10-7
2-[[2-[[(3R,3aR,6S,6aS)-6-fluoro-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3-yl]oxy]-6-chloro-5-(4-phenylphenyl)imidazo[4,5-b]pyridin-1-yl]methoxy]ethyl-trimethyl-silane

Guidance literature:: Multi-step reaction with 10 steps

1.1: N-chloro-succinimide; acetic acid / 80 °C

2.1: sodium iodide; acetic acid / 2 h / 90 °C

3.1: ethanol / tin(II) chloride hydrate / 0.5 h / 70 °C

4.1: dmap / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

5.1: potassium hydroxide / ethanol / 0.5 h / 20 °C

5.2: 1 h / 20 °C

6.1: Oxone / acetonitrile; water / 18 h / 20 °C

7.1: potassium phosphate / palladium diacetate; catacxium A / water; tetrahydrofuran / 42 h / 45 °C / Inert atmosphere

8.1: triethylamine / tetrahydrofuran / 0.25 h / 0 - 20 °C

9.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / ISOPROPYLAMIDE / 20 °C

10.1: diethylamino-sulfur trifluoride / dichloromethane / 21.5 h / 0 - 20 °C

With Oxone; potassium phosphate; N-chloro-succinimide; ethanol; diethylamino-sulfur trifluoride; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; sodium iodide; potassium hydroxide; dmap; tin(II) chloride hydrate; palladium diacetate; catacxium A; In tetrahydrofuran; ethanol; dichloromethane; ISOPROPYLAMIDE; water; acetonitrile;

Reference yield:

: 203794-33-6
2-amino-5,6-dichloro-3-nitropyridine

: 1394374-10-7
2-[[2-[[(3R,3aR,6S,6aS)-6-fluoro-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3-yl]oxy]-6-chloro-5-(4-phenylphenyl)imidazo[4,5-b]pyridin-1-yl]methoxy]ethyl-trimethyl-silane

Guidance literature:: Multi-step reaction with 9 steps

1.1: sodium iodide; acetic acid / 2 h / 90 °C

2.1: ethanol / tin(II) chloride hydrate / 0.5 h / 70 °C

3.1: dmap / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

4.1: potassium hydroxide / ethanol / 0.5 h / 20 °C

4.2: 1 h / 20 °C

5.1: Oxone / acetonitrile; water / 18 h / 20 °C

6.1: potassium phosphate / palladium diacetate; catacxium A / water; tetrahydrofuran / 42 h / 45 °C / Inert atmosphere

7.1: triethylamine / tetrahydrofuran / 0.25 h / 0 - 20 °C

8.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / ISOPROPYLAMIDE / 20 °C

9.1: diethylamino-sulfur trifluoride / dichloromethane / 21.5 h / 0 - 20 °C

With Oxone; potassium phosphate; ethanol; diethylamino-sulfur trifluoride; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; sodium iodide; potassium hydroxide; dmap; tin(II) chloride hydrate; palladium diacetate; catacxium A; In tetrahydrofuran; ethanol; dichloromethane; ISOPROPYLAMIDE; water; acetonitrile;