(1S,2S)-2-dibenzylamino-1-phenyl-3-triphenylmethoxy-1-propanol

Base Information

• Chemical Name: (1S,2S)-2-dibenzylamino-1-phenyl-3-triphenylmethoxy-1-propanol
• CAS No.: 155595-11-2
• Molecular Formula: C₄₂H₃₉NO₂
• Molecular Weight: 589.777
• Mol file: 155595-11-2.mol

Synonyms:(1S,2S)-2-dibenzylamino-1-phenyl-3-triphenylmethoxy-1-propanol

Chemical Property of (1S,2S)-2-dibenzylamino-1-phenyl-3-triphenylmethoxy-1-propanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1S,2S)-2-dibenzylamino-1-phenyl-3-triphenylmethoxy-1-propanol

There total 3 articles about (1S,2S)-2-dibenzylamino-1-phenyl-3-triphenylmethoxy-1-propanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

(1S,2S)-2-(dibenzylamino)-1-phenylpropane-1,3-diol (155595-12-3) + trityl chloride (76-83-5) → (1S,2S)-2-dibenzylamino-1-phenyl-3-triphenylmethoxy-1-propanol (155595-11-2)

Guidance literature:

With dmap; triethylamine; In dichloromethane; for 8h; Ambient temperature;

DOI:10.1016/S0040-4020(01)89668-X

Reference yield:

(1S,2S)-2-amino-1-phenyl-1,3-diol (28143-91-1) → (1S,2S)-2-dibenzylamino-1-phenyl-3-triphenylmethoxy-1-propanol (155595-11-2)

Guidance literature:

Multi-step reaction with 2 steps

1: K₂CO₃ / H₂O / 1 h / Heating

2: 79 percent / Et₃N, 4-dimethylaminopyridine / CH₂Cl₂ / 8 h / Ambient temperature

With dmap; potassium carbonate; triethylamine; In dichloromethane; water;

DOI:10.1016/S0040-4020(01)89668-X

Reference yield:

benzyl bromide (100-39-0) → (1S,2S)-2-dibenzylamino-1-phenyl-3-triphenylmethoxy-1-propanol (155595-11-2)

Guidance literature:

Multi-step reaction with 2 steps

1: K₂CO₃ / H₂O / 1 h / Heating

2: 79 percent / Et₃N, 4-dimethylaminopyridine / CH₂Cl₂ / 8 h / Ambient temperature

With dmap; potassium carbonate; triethylamine; In dichloromethane; water;

DOI:10.1016/S0040-4020(01)89668-X

upstream raw materials:

(1S,2S)-2-(dibenzylamino)-1-phenylpropane-1,3-diol

trityl chloride

(1S,2S)-2-amino-1-phenyl-1,3-diol

benzyl bromide

Downstream raw materials:

methyl E-(5S,6S)-dibenzylamino-5-phenyl-7-triphenylmethoxy-4-thia-2-heptenoate

(1S,2S)-2-dibenzylamino-1-phenyl-3-triphenylmethoxy-1-propane-1-thiol

(1S,4S,5R,7S,8S)-2-benzyl-8-dibenzylamino-4-methoxycarbonyl-7-phenyl-3-oxa-6-thia-2-azabicyclo<3.3.0>octane

methyl E-(5S,6S)-dibenzylamino-7-hydroxy-5-phenyl-4-thia-2-heptenoate