[(2R,4R,6S)-6-(2-Oxo-ethyl)-2-phenyl-[1,3]dioxan-4-yl]-acetic acid methyl ester

Base Information

Chemical Name:[(2R,4R,6S)-6-(2-Oxo-ethyl)-2-phenyl-[1,3]dioxan-4-yl]-acetic acid methyl ester
CAS No.:714966-49-1
Molecular Formula:C₁₅H₁₈O₅
Molecular Weight:278.305
Hs Code.:

Synonyms:[(2R,4R,6S)-6-(2-Oxo-ethyl)-2-phenyl-[1,3]dioxan-4-yl]-acetic acid methyl ester

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Chemical Property of [(2R,4R,6S)-6-(2-Oxo-ethyl)-2-phenyl-[1,3]dioxan-4-yl]-acetic acid methyl ester

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Technology Process of [(2R,4R,6S)-6-(2-Oxo-ethyl)-2-phenyl-[1,3]dioxan-4-yl]-acetic acid methyl ester

There total 5 articles about [(2R,4R,6S)-6-(2-Oxo-ethyl)-2-phenyl-[1,3]dioxan-4-yl]-acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 714966-62-8
(2R,4R,6R)-4-(carbomethoxymethyl)-6-(2-hydroxyethyl)-2-phenyl-1,3-dioxane

: 714966-49-1
[(2R,4R,6S)-6-(2-Oxo-ethyl)-2-phenyl-[1,3]dioxan-4-yl]-acetic acid methyl ester

Guidance literature:: With pyridine-SO₃ complex; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃; for 0.5h;
DOI:10.1021/ol049331x

Reference yield:

: 112897-09-3
(3S)-1-{[t-butyl(diphenyl)silyl]oxy}hex-5-en-3-ol

: 714966-49-1
[(2R,4R,6S)-6-(2-Oxo-ethyl)-2-phenyl-[1,3]dioxan-4-yl]-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: Hoveyda's catalyst / CH₂Cl₂ / 7 h / Heating

2: t-BuOK / tetrahydrofuran / 0 °C

3: (HF)3*Et₃N / acetonitrile / 24 h / 45 °C

4: iPr₂NEt; DMSO; SO₃*pyridine / CH₂Cl₂ / 0.5 h / 0 °C

With pyridine-SO₃ complex; potassium tert-butylate; dimethyl sulfoxide; triethylamine tris(hydrogen fluoride); N-ethyl-N,N-diisopropylamine; dichloro(o-isporopoxyphenylmethylene)(triphenylphosphine)ruthenium(II); In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1021/ol049331x

Reference yield:

: 100-52-7
benzaldehyde

: 714966-49-1
[(2R,4R,6S)-6-(2-Oxo-ethyl)-2-phenyl-[1,3]dioxan-4-yl]-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: t-BuOK / tetrahydrofuran / 0 °C

2: (HF)3*Et₃N / acetonitrile / 24 h / 45 °C

3: iPr₂NEt; DMSO; SO₃*pyridine / CH₂Cl₂ / 0.5 h / 0 °C

With pyridine-SO₃ complex; potassium tert-butylate; dimethyl sulfoxide; triethylamine tris(hydrogen fluoride); N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1021/ol049331x