(2R,4R,6R)-4-(carbomethoxymethyl)-6-(2-hydroxyethyl)-2-phenyl-1,3-dioxane

Base Information

Chemical Name:(2R,4R,6R)-4-(carbomethoxymethyl)-6-(2-hydroxyethyl)-2-phenyl-1,3-dioxane
CAS No.:714966-62-8
Molecular Formula:C₁₅H₂₀O₅
Molecular Weight:280.321
Hs Code.:

Synonyms:(2R,4R,6R)-4-(carbomethoxymethyl)-6-(2-hydroxyethyl)-2-phenyl-1,3-dioxane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,4R,6R)-4-(carbomethoxymethyl)-6-(2-hydroxyethyl)-2-phenyl-1,3-dioxane

Chemical Property:

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Technology Process of (2R,4R,6R)-4-(carbomethoxymethyl)-6-(2-hydroxyethyl)-2-phenyl-1,3-dioxane

There total 4 articles about (2R,4R,6R)-4-(carbomethoxymethyl)-6-(2-hydroxyethyl)-2-phenyl-1,3-dioxane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 714966-48-0
(2R,4R,6R)-4-(carbomethoxymethyl)-6-[2-(t-butyldiphenylsilyloxy)ethyl]-2-phenyl-1,3-dioxane

: 714966-62-8
(2R,4R,6R)-4-(carbomethoxymethyl)-6-(2-hydroxyethyl)-2-phenyl-1,3-dioxane

Guidance literature:: With triethylamine tris(hydrogen fluoride); In acetonitrile; at 45 ℃; for 24h;
DOI:10.1021/ol049331x

Reference yield:

: 112897-09-3
(3S)-1-{[t-butyl(diphenyl)silyl]oxy}hex-5-en-3-ol

: 714966-62-8
(2R,4R,6R)-4-(carbomethoxymethyl)-6-(2-hydroxyethyl)-2-phenyl-1,3-dioxane

Guidance literature:: Multi-step reaction with 3 steps

1: Hoveyda's catalyst / CH₂Cl₂ / 7 h / Heating

2: t-BuOK / tetrahydrofuran / 0 °C

3: (HF)3*Et₃N / acetonitrile / 24 h / 45 °C

With potassium tert-butylate; triethylamine tris(hydrogen fluoride); dichloro(o-isporopoxyphenylmethylene)(triphenylphosphine)ruthenium(II); In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1021/ol049331x

Reference yield:

: 100-52-7
benzaldehyde

: 714966-62-8
(2R,4R,6R)-4-(carbomethoxymethyl)-6-(2-hydroxyethyl)-2-phenyl-1,3-dioxane

Guidance literature:: Multi-step reaction with 2 steps

1: t-BuOK / tetrahydrofuran / 0 °C

2: (HF)3*Et₃N / acetonitrile / 24 h / 45 °C

With potassium tert-butylate; triethylamine tris(hydrogen fluoride); In tetrahydrofuran; acetonitrile;
DOI:10.1021/ol049331x