(1S,2S)-2,3-dihydro-1'-(((2-amino-7,7-dimethylbicyclo<2.2.1>hept-1-yl)methyl)sulfonyl)spiro(1H-indene-1,4'-piperidine)

Base Information

• Chemical Name: (1S,2S)-2,3-dihydro-1'-(((2-amino-7,7-dimethylbicyclo<2.2.1>hept-1-yl)methyl)sulfonyl)spiro(1H-indene-1,4'-piperidine)
• CAS No.: 142643-14-9
• Molecular Formula: C₂₃H₃₄N₂O₂S
• Molecular Weight: 402.601
• Mol file: 142643-14-9.mol

Synonyms:(1S,2S)-2,3-dihydro-1'-(((2-amino-7,7-dimethylbicyclo<2.2.1>hept-1-yl)methyl)sulfonyl)spiro(1H-indene-1,4'-piperidine)

Chemical Property of (1S,2S)-2,3-dihydro-1'-(((2-amino-7,7-dimethylbicyclo<2.2.1>hept-1-yl)methyl)sulfonyl)spiro(1H-indene-1,4'-piperidine)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1S,2S)-2,3-dihydro-1'-(((2-amino-7,7-dimethylbicyclo<2.2.1>hept-1-yl)methyl)sulfonyl)spiro(1H-indene-1,4'-piperidine)

There total 1 articles about (1S,2S)-2,3-dihydro-1'-(((2-amino-7,7-dimethylbicyclo<2.2.1>hept-1-yl)methyl)sulfonyl)spiro(1H-indene-1,4'-piperidine) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

spiro(1H-indene-1,4'-piperidine) hydrochloride (137730-67-7) → (1S,2S)-2,3-dihydro-1'-(((2-amino-7,7-dimethylbicyclo<2.2.1>hept-1-yl)methyl)sulfonyl)spiro(1H-indene-1,4'-piperidine) (142643-14-9)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / CH₂Cl₂

2: NH₂ON-HCl, pyridine / 12 h

3: H₂ / Raney nickel / ethanol

With pyridine; hydroxylamine hydrochloride; hydrogen; triethylamine; nickel; In ethanol; dichloromethane;

DOI:10.1016/0960-894X(96)00213-2

Reference yield: 89.0%

4-Nitrophenyl chloroformate (7693-46-1) + (1S,2S)-2,3-dihydro-1'-(((2-amino-7,7-dimethylbicyclo<2.2.1>hept-1-yl)methyl)sulfonyl)spiro(1H-indene-1,4'-piperidine) (142643-14-9) → C30H37N3O6S (142643-28-5)

Guidance literature:

With triethylamine; In tetrahydrofuran; for 3h; Ambient temperature;

DOI:10.1021/jm00077a002

Reference yield:

(1S,2S)-2,3-dihydro-1'-(((2-amino-7,7-dimethylbicyclo<2.2.1>hept-1-yl)methyl)sulfonyl)spiro(1H-indene-1,4'-piperidine) (142643-14-9) + N-(tert-butoxycarbonyl)-L-histidine (17791-52-5) → C34H49N5O5S

Guidance literature:

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In acetonitrile; Ambient temperature;

DOI:10.1021/jm00077a002

upstream raw materials:

spiro(1H-indene-1,4'-piperidine) hydrochloride

Downstream raw materials:

C₃₀H₃₇N₃O₆S