N-(2-bromobenzyl)-2-fluoro-N-methylaniline

Base Information

• Chemical Name: N-(2-bromobenzyl)-2-fluoro-N-methylaniline
• CAS No.: 475039-96-4
• Molecular Formula: C₁₄H₁₃BrFN
• Molecular Weight: 294.166
• Mol file: 475039-96-4.mol

Synonyms:N-(2-bromobenzyl)-2-fluoro-N-methylaniline

Chemical Property of N-(2-bromobenzyl)-2-fluoro-N-methylaniline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of N-(2-bromobenzyl)-2-fluoro-N-methylaniline

There total 2 articles about N-(2-bromobenzyl)-2-fluoro-N-methylaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

2-fluoro-N-methylaniline (1978-38-7) + 1-Bromo-2-bromomethyl-benzene (3433-80-5) → N-(2-bromobenzyl)-2-fluoro-N-methylaniline (475039-96-4)

Guidance literature:

2-fluoro-N-methylaniline; With n-butyllithium; In tetrahydrofuran; hexane; at -50 - 20 ℃; for 1h;

1-Bromo-2-bromomethyl-benzene; In tetrahydrofuran; hexane; for 5.25h; Further stages.;

DOI:10.1002/1521-3765(20020503)8:9<2034::AID-CHEM2034>3.0.CO;2-I

Reference yield:

2-Fluoroaniline (348-54-9) → N-(2-bromobenzyl)-2-fluoro-N-methylaniline (475039-96-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: BuLi / hexane; tetrahydrofuran / 1.25 h / -50 - 20 °C

1.2: 80 percent / hexane; tetrahydrofuran / 5.25 h

2.1: BuLi / hexane; tetrahydrofuran / 1 h / -50 - 20 °C

2.2: 72 percent / hexane; tetrahydrofuran / 5.25 h

With n-butyllithium; In tetrahydrofuran; hexane;

DOI:10.1002/1521-3765(20020503)8:9<2034::AID-CHEM2034>3.0.CO;2-I

Reference yield: 80.0%

diphenyldisulfane (882-33-7) + N-(2-bromobenzyl)-2-fluoro-N-methylaniline (475039-96-4) → 5,6-dihydro-5-methyl-1-phenylthiophenanthridine

Guidance literature:

N-(2-bromobenzyl)-2-fluoro-N-methylaniline; With tert.-butyl lithium; In tetrahydrofuran; pentane; at -110 - 20 ℃;

diphenyldisulfane; In tetrahydrofuran; pentane; at 20 ℃; for 3h; Further stages.;

DOI:10.1002/1521-3765(20020503)8:9<2034::AID-CHEM2034>3.0.CO;2-I

upstream raw materials:

2-fluoro-N-methylaniline

1-Bromo-2-bromomethyl-benzene

2-Fluoroaniline

Refernces