exo/endo-5'-O-benzyl-N⁶-dimethoxytrityl-2',3'-O-p-methoxybenzylideneadenosine

Base Information

Chemical Name:exo/endo-5'-O-benzyl-N⁶-dimethoxytrityl-2',3'-O-p-methoxybenzylideneadenosine
CAS No.:286365-19-3
Molecular Formula:C₄₆H₄₃N₅O₇
Molecular Weight:777.877
Hs Code.:

exo/endo-5'-O-benzyl-N<sup>6</sup>-dimethoxytrityl-2',3'-O-p-methoxybenzylideneadenosine

Synonyms:exo/endo-5'-O-benzyl-N⁶-dimethoxytrityl-2',3'-O-p-methoxybenzylideneadenosine

Suppliers and Price of exo/endo-5'-O-benzyl-N⁶-dimethoxytrityl-2',3'-O-p-methoxybenzylideneadenosine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of exo/endo-5'-O-benzyl-N⁶-dimethoxytrityl-2',3'-O-p-methoxybenzylideneadenosine

Chemical Property:

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Technology Process of exo/endo-5'-O-benzyl-N⁶-dimethoxytrityl-2',3'-O-p-methoxybenzylideneadenosine

There total 7 articles about exo/endo-5'-O-benzyl-N⁶-dimethoxytrityl-2',3'-O-p-methoxybenzylideneadenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 100-44-7
benzyl chloride

: 286365-18-2
endo/exo-N⁶-dimethoxytrityl-2',3'-O-p-methoxybenzylideneadenosine

: 286365-19-3
exo/endo-5'-O-benzyl-N⁶-dimethoxytrityl-2',3'-O-p-methoxybenzylideneadenosine

Guidance literature:: With potassium hydroxide; In 1,4-dioxane; benzene; Heating;
DOI:10.1016/S0957-4166(99)00491-7

Reference yield:

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 286365-19-3
exo/endo-5'-O-benzyl-N⁶-dimethoxytrityl-2',3'-O-p-methoxybenzylideneadenosine

Guidance literature:: Multi-step reaction with 3 steps

2: conc. aq. NH₄OH

3: 95 percent / KOH / benzene; dioxane / Heating

With potassium hydroxide; ammonium hydroxide; In 1,4-dioxane; benzene; 1: Tritylation / 2: Desilylation / 3: benzylation;
DOI:10.1016/S0957-4166(99)00491-7

Reference yield:

: 123-11-5
4-methoxy-benzaldehyde

: 286365-19-3
exo/endo-5'-O-benzyl-N⁶-dimethoxytrityl-2',3'-O-p-methoxybenzylideneadenosine

Guidance literature:: Multi-step reaction with 5 steps

1: 90 percent / triethyl orthoformate; pTSA / 35 - 40 °C

2: pyridine

4: conc. aq. NH₄OH

5: 95 percent / KOH / benzene; dioxane / Heating

With pyridine; potassium hydroxide; ammonium hydroxide; toluene-4-sulfonic acid; orthoformic acid triethyl ester; In 1,4-dioxane; benzene; 1: Condensation / 2: Silylation / 3: Tritylation / 4: Desilylation / 5: benzylation;
DOI:10.1016/S0957-4166(99)00491-7