[1-benzothiene-2-yl-(5-bromo-2-fluorophenyl)methoxy](tert-butyl)dimethylsilane

Base Information

• Chemical Name: [1-benzothiene-2-yl-(5-bromo-2-fluorophenyl)methoxy](tert-butyl)dimethylsilane
• CAS No.: 761424-75-3
• Molecular Formula: C₂₁H₂₄BrFOSSi
• Molecular Weight: 451.475
• Mol file: 761424-75-3.mol

Synonyms:[1-benzothiene-2-yl-(5-bromo-2-fluorophenyl)methoxy](tert-butyl)dimethylsilane

Chemical Property of [1-benzothiene-2-yl-(5-bromo-2-fluorophenyl)methoxy](tert-butyl)dimethylsilane

Chemical Property:

Purity/Quality:

95%-98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [1-benzothiene-2-yl-(5-bromo-2-fluorophenyl)methoxy](tert-butyl)dimethylsilane

There total 2 articles about [1-benzothiene-2-yl-(5-bromo-2-fluorophenyl)methoxy](tert-butyl)dimethylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

(1-benzothiophen-2-yl)(5-bromo-2-fluorophenyl)methanol (1034305-11-7) + tert-butyldimethylsilyl chloride (18162-48-6) → [1-benzothiene-2-yl-(5-bromo-2-fluorophenyl)methoxy](tert-butyl)dimethylsilane (761424-75-3)

Guidance literature:

With 1H-imidazole; dmap; In N,N-dimethyl-formamide; at 20 ℃; for 7h;

Reference yield:

→ [1-benzothiene-2-yl-(5-bromo-2-fluorophenyl)methoxy](tert-butyl)dimethylsilane (761424-75-3)

Guidance literature:

Reference yield: 50.2%

(3R,4S,5R,6R)-3,4,5-tris(benzyloxy)-6-((benzyloxy)methyl)tetrahydro-2H-pyran-2-one (13096-62-3) + [1-benzothiene-2-yl-(5-bromo-2-fluorophenyl)methoxy](tert-butyl)dimethylsilane (761424-75-3) → 1-C-[3-(1-benzothien-2-yl{tert-butyl-(dimethyl)silyloxy}methyl)-4-fluorophenyl]-2,3,4,6-tetra-O-benzyl-D-glucopyranose

Guidance literature:

[1-benzothiene-2-yl-(5-bromo-2-fluorophenyl)methoxy](tert-butyl)dimethylsilane; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; Inert atmosphere;

(3R,4S,5R,6R)-3,4,5-tris(benzyloxy)-6-((benzyloxy)methyl)tetrahydro-2H-pyran-2-one; In tetrahydrofuran; hexane; at -78 - 0 ℃; Inert atmosphere;

With water; ammonium chloride; In tetrahydrofuran; hexane;

upstream raw materials:

(1-benzothiophen-2-yl)(5-bromo-2-fluorophenyl)methanol

tert-butyldimethylsilyl chloride