7-(4-acetoxybut-1-yl)-2-acetylamino-6-(2',4',6'-triisopropylbenzenesulfonyloxy)-7H-purine

Base Information

Chemical Name:7-(4-acetoxybut-1-yl)-2-acetylamino-6-(2',4',6'-triisopropylbenzenesulfonyloxy)-7H-purine
CAS No.:256945-24-1
Molecular Formula:C₂₈H₃₉N₅O₆S
Molecular Weight:573.714
Hs Code.:

Synonyms:7-(4-acetoxybut-1-yl)-2-acetylamino-6-(2',4',6'-triisopropylbenzenesulfonyloxy)-7H-purine

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Chemical Property of 7-(4-acetoxybut-1-yl)-2-acetylamino-6-(2',4',6'-triisopropylbenzenesulfonyloxy)-7H-purine

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Technology Process of 7-(4-acetoxybut-1-yl)-2-acetylamino-6-(2',4',6'-triisopropylbenzenesulfonyloxy)-7H-purine

There total 10 articles about 7-(4-acetoxybut-1-yl)-2-acetylamino-6-(2',4',6'-triisopropylbenzenesulfonyloxy)-7H-purine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 6553-96-4
2,4,6-triisopropylphenylsulfonyl chloride

: 256945-23-0
N²-acetyl-7-(4-acetoxybut-1-yl)guanine

: 256945-24-1
7-(4-acetoxybut-1-yl)-2-acetylamino-6-(2',4',6'-triisopropylbenzenesulfonyloxy)-7H-purine

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 20 ℃;
DOI:10.1055/s-2004-829174

Reference yield:

: 17495-12-4
2-amino-7-benzyl-1H-purin-6(7H)-one

: 256945-24-1
7-(4-acetoxybut-1-yl)-2-acetylamino-6-(2',4',6'-triisopropylbenzenesulfonyloxy)-7H-purine

Guidance literature:: Multi-step reaction with 8 steps

1.1: 93 percent / 1-methyl-pyrrolidin-2-one / 1 h / 150 °C

2.1: 90 percent / 1-methyl-pyrrolidin-2-one / 2 h / 120 °C

3.1: HCOONH₄ / Pd/C / methanol / 4 h / Heating

3.2: 71 percent / NH₄OH / 1 h / Heating

4.1: 46 percent / 1-methyl-pyrrolidin-2-one / 4 h / 150 °C

5.1: 99 percent / 1-methyl-pyrrolidin-2-one / 2 h / 120 °C

6.1: 71 percent / HCOONH₄ / Pd/C / methanol / 4 h / Heating

7.1: 90 percent / 1-methyl-pyrrolidin-2-one / 10 h / Heating

8.1: 96 percent / Et₃N; DMAP / CH₂Cl₂ / 20 °C

With dmap; ammonium formate; triethylamine; palladium on activated charcoal; In 1-methyl-pyrrolidin-2-one; methanol; dichloromethane;
DOI:10.1055/s-2004-829174

Reference yield:

: 17495-10-2
N²-acetyl-7-benzylguanine

: 256945-24-1
7-(4-acetoxybut-1-yl)-2-acetylamino-6-(2',4',6'-triisopropylbenzenesulfonyloxy)-7H-purine

Guidance literature:: Multi-step reaction with 7 steps

1.1: 90 percent / 1-methyl-pyrrolidin-2-one / 2 h / 120 °C

2.1: HCOONH₄ / Pd/C / methanol / 4 h / Heating

2.2: 71 percent / NH₄OH / 1 h / Heating

3.1: 46 percent / 1-methyl-pyrrolidin-2-one / 4 h / 150 °C

4.1: 99 percent / 1-methyl-pyrrolidin-2-one / 2 h / 120 °C

5.1: 71 percent / HCOONH₄ / Pd/C / methanol / 4 h / Heating

6.1: 90 percent / 1-methyl-pyrrolidin-2-one / 10 h / Heating

7.1: 96 percent / Et₃N; DMAP / CH₂Cl₂ / 20 °C

With dmap; ammonium formate; triethylamine; palladium on activated charcoal; In 1-methyl-pyrrolidin-2-one; methanol; dichloromethane;
DOI:10.1055/s-2004-829174