2-amino-5-{8-[3-(aminosulfonyl)phenyl]-1,5-naphthyridin-2-yl}-N,N-dimethyl-3-pyridinesulfonamide

Base Information

Chemical Name:2-amino-5-{8-[3-(aminosulfonyl)phenyl]-1,5-naphthyridin-2-yl}-N,N-dimethyl-3-pyridinesulfonamide
CAS No.:1092565-18-8
Molecular Formula:C₂₁H₂₀N₆O₄S₂
Molecular Weight:484.56
Hs Code.:

Synonyms:2-amino-5-{8-[3-(aminosulfonyl)phenyl]-1,5-naphthyridin-2-yl}-N,N-dimethyl-3-pyridinesulfonamide

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Chemical Property of 2-amino-5-{8-[3-(aminosulfonyl)phenyl]-1,5-naphthyridin-2-yl}-N,N-dimethyl-3-pyridinesulfonamide

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Technology Process of 2-amino-5-{8-[3-(aminosulfonyl)phenyl]-1,5-naphthyridin-2-yl}-N,N-dimethyl-3-pyridinesulfonamide

There total 7 articles about 2-amino-5-{8-[3-(aminosulfonyl)phenyl]-1,5-naphthyridin-2-yl}-N,N-dimethyl-3-pyridinesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 19.0%

: 1083326-15-1
2-amino-5-bromo-N,N-dimethylpyridine-3-sulfonamide

: 1092565-16-6
8-[3-(aminosulfonyl)phenyl]-1,5-naphthyridin-2-yltrifluoromethanesulfonate

: 1092565-18-8
2-amino-5-{8-[3-(aminosulfonyl)phenyl]-1,5-naphthyridin-2-yl}-N,N-dimethyl-3-pyridinesulfonamide

Guidance literature:: 2-amino-5-bromo-N,N-dimethylpyridine-3-sulfonamide; With potassium acetate; bis(pinacol)diborane; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; at 120 ℃; for 0.5h; microwave irradiation;

8-[3-(aminosulfonyl)phenyl]-1,5-naphthyridin-2-yltrifluoromethanesulfonate; With water; sodium hydrogencarbonate; In 1,4-dioxane; at 120 ℃; for 1h; microwave irradiation;

Reference yield:

: 486422-08-6
3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzene-1-sulfonamide

: 1092565-18-8
2-amino-5-{8-[3-(aminosulfonyl)phenyl]-1,5-naphthyridin-2-yl}-N,N-dimethyl-3-pyridinesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: water; sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 6 h / 100 °C

2.1: hydrogenchloride; water / 1,4-dioxane / 66 h / 100 °C

3.1: pyridine / 3 h / 20 °C

4.1: potassium acetate; bis(pinacol)diborane / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 0.5 h / 120 °C / microwave irradiation

4.2: 1 h / 120 °C / microwave irradiation

With pyridine; hydrogenchloride; water; potassium acetate; sodium hydrogencarbonate; bis(pinacol)diborane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane;

Reference yield:

: 394223-86-0
6-methoxy-1,5-naphthyridin-4-yl trifluoromethanesulfonate

: 1092565-18-8
2-amino-5-{8-[3-(aminosulfonyl)phenyl]-1,5-naphthyridin-2-yl}-N,N-dimethyl-3-pyridinesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: water; sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 6 h / 100 °C

2.1: hydrogenchloride; water / 1,4-dioxane / 66 h / 100 °C

3.1: pyridine / 3 h / 20 °C

4.1: potassium acetate; bis(pinacol)diborane / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 0.5 h / 120 °C / microwave irradiation

4.2: 1 h / 120 °C / microwave irradiation

With pyridine; hydrogenchloride; water; potassium acetate; sodium hydrogencarbonate; bis(pinacol)diborane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane;