6-bromo-3-[4-(2-cyclopropyl-2-hydroxy-ethoxy)-3-methoxy-phenyl]-3H-pyrrolo[2,1-f][1,2,4]triazin-4-one

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Chemical Name:6-bromo-3-[4-(2-cyclopropyl-2-hydroxy-ethoxy)-3-methoxy-phenyl]-3H-pyrrolo[2,1-f][1,2,4]triazin-4-one
CAS No.:1221420-50-3
Molecular Formula:C₁₈H₁₈BrN₃O₄
Molecular Weight:420.263
Hs Code.:

Synonyms:6-bromo-3-[4-(2-cyclopropyl-2-hydroxy-ethoxy)-3-methoxy-phenyl]-3H-pyrrolo[2,1-f][1,2,4]triazin-4-one

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Chemical Property of 6-bromo-3-[4-(2-cyclopropyl-2-hydroxy-ethoxy)-3-methoxy-phenyl]-3H-pyrrolo[2,1-f][1,2,4]triazin-4-one

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Technology Process of 6-bromo-3-[4-(2-cyclopropyl-2-hydroxy-ethoxy)-3-methoxy-phenyl]-3H-pyrrolo[2,1-f][1,2,4]triazin-4-one

There total 8 articles about 6-bromo-3-[4-(2-cyclopropyl-2-hydroxy-ethoxy)-3-methoxy-phenyl]-3H-pyrrolo[2,1-f][1,2,4]triazin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1221420-48-9
4-bromo-1-(dimethylamino-methyleneamino)-1H-pyrrole-2-carboxylic acid [4-(2-cyclopropyl-2-hydroxy-ethoxy)-3-methoxy-phenyl]-amide

: 1221420-50-3
6-bromo-3-[4-(2-cyclopropyl-2-hydroxy-ethoxy)-3-methoxy-phenyl]-3H-pyrrolo[2,1-f][1,2,4]triazin-4-one

Guidance literature:: acetic acid; In acetonitrile; at 160 ℃; for 0.5h; Irradiation;

Reference yield:

: C₂₀H₂₅BrN₄O₄

: 1221420-50-3
6-bromo-3-[4-(2-cyclopropyl-2-hydroxy-ethoxy)-3-methoxy-phenyl]-3H-pyrrolo[2,1-f][1,2,4]triazin-4-one

Guidance literature:: With acetic acid; In acetonitrile; at 160 ℃; for 1h; Microwave irradiation;
DOI:10.1016/j.bmcl.2015.09.018

Reference yield:

: 1208361-39-0
1-amino-4-bromo-1H-pyrrole-2-carboxylic acid methyl ester

: 1221420-50-3
6-bromo-3-[4-(2-cyclopropyl-2-hydroxy-ethoxy)-3-methoxy-phenyl]-3H-pyrrolo[2,1-f][1,2,4]triazin-4-one

Guidance literature:: Multi-step reaction with 4 steps

1: 3 h / 60 °C

2: lithium hydroxide / water; tetrahydrofuran / 60 °C

3: benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.25 h / 20 °C

4: acetic acid / acetonitrile / 1 h / 160 °C / Microwave irradiation

With benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmcl.2015.09.018