ethyl 1-benzoyl-2-cyano-4-iodopyrrole-3-acetate

Base Information

Chemical Name:ethyl 1-benzoyl-2-cyano-4-iodopyrrole-3-acetate
CAS No.:87721-23-1
Molecular Formula:C₁₆H₁₃IN₂O₃
Molecular Weight:408.195
Hs Code.:

Synonyms:ethyl 1-benzoyl-2-cyano-4-iodopyrrole-3-acetate

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Chemical Property of ethyl 1-benzoyl-2-cyano-4-iodopyrrole-3-acetate

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Technology Process of ethyl 1-benzoyl-2-cyano-4-iodopyrrole-3-acetate

There total 5 articles about ethyl 1-benzoyl-2-cyano-4-iodopyrrole-3-acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.5%

: 98-88-4
benzoyl chloride

: 87721-19-5
ethyl 2-cyano-4-iodopyrrole-3-acetate

: 87721-23-1
ethyl 1-benzoyl-2-cyano-4-iodopyrrole-3-acetate

Guidance literature:: With sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; In dichloromethane; at 0 ℃; for 2h;

Reference yield:

: 87630-41-9
ethyl 2-oxo-2-(1H-pyrrol-3-yl)acetate

: 87721-23-1
ethyl 1-benzoyl-2-cyano-4-iodopyrrole-3-acetate

Guidance literature:: Multi-step reaction with 4 steps

1: 67 percent / W₇³ Raney nickel / ethanol; H₂O; toluene / 4.5 h / Ambient temperature

2: 53 percent / CSI / CH₂Cl₂; acetonitrile / 2.5 h / -42 °C

3: 97 percent / iodic acid/iodine, conc. sulfuric acid / CCl₄; H₂O; acetic acid / 24 h / Ambient temperature

4: 99.5 percent / NaOH, tetrabutylammonium hydrogen sulfate / CH₂Cl₂ / 2 h / 0 °C

With sodium hydroxide; isocyanate de chlorosulfonyle; sulfuric acid; iodine; tetra(n-butyl)ammonium hydrogensulfate; iodic acid; W₇³ Raney nickel; In tetrachloromethane; ethanol; dichloromethane; water; acetic acid; toluene; acetonitrile;

Reference yield:

: 87721-13-9
ethyl 2-formylpyrrole-4-glyoxalate

: 87721-23-1
ethyl 1-benzoyl-2-cyano-4-iodopyrrole-3-acetate

Guidance literature:: Multi-step reaction with 5 steps

1: 92 percent / 5percent palladium on charcoal / 1,3,5-trimethyl-benzene / 6 h / Heating

2: 67 percent / W₇³ Raney nickel / ethanol; H₂O; toluene / 4.5 h / Ambient temperature

3: 53 percent / CSI / CH₂Cl₂; acetonitrile / 2.5 h / -42 °C

4: 97 percent / iodic acid/iodine, conc. sulfuric acid / CCl₄; H₂O; acetic acid / 24 h / Ambient temperature

5: 99.5 percent / NaOH, tetrabutylammonium hydrogen sulfate / CH₂Cl₂ / 2 h / 0 °C

With sodium hydroxide; isocyanate de chlorosulfonyle; sulfuric acid; iodine; tetra(n-butyl)ammonium hydrogensulfate; iodic acid; palladium on activated charcoal; W₇³ Raney nickel; In tetrachloromethane; ethanol; dichloromethane; water; acetic acid; toluene; acetonitrile; 1,3,5-trimethyl-benzene;