N-(3-Amino-4-methylphenyl)acetamide

Base Information

• Chemical Name: N-(3-Amino-4-methylphenyl)acetamide
• CAS No.: 6375-16-2
• Molecular Formula: C9H12 N2 O
• Molecular Weight: 164.207
• European Community (EC) Number: 228-933-0
• UNII: HTV7P28A6R
• DSSTox Substance ID: DTXSID1064293
• Nikkaji Number: J8.396H
• Wikidata: Q27280094
• Mol file: 6375-16-2.mol

Synonyms:4-acetoxyamino-2-aminotoluene;4-acetylamino-2-aminotoluene;N(4)-Ac-TDA;N(4)-acetyl-2,4-toluenediamine

Chemical Property of N-(3-Amino-4-methylphenyl)acetamide

Chemical Property:

• Vapor Pressure: 1.52E-16mmHg at 25°C
• Boiling Point: 645.4°C at 760 mmHg
• Flash Point: 213.5°C
• PSA: 55.12000
• Density: 1.109g/cm³
• LogP: 2.18980
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 164.094963011
• Heavy Atom Count: 12
• Complexity: 170

Purity/Quality:

98%min ^*data from raw suppliers

N-(3-Amino-4-methylphenyl)acetamide Aldrich ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(C=C(C=C1)NC(=O)C)N

Technology Process of N-(3-Amino-4-methylphenyl)acetamide

There total 9 articles about N-(3-Amino-4-methylphenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

4-acetylamino-2-nitrotoluene (2719-14-4) → 2-amino-4-acetylaminotoluene (6375-16-2)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 2h;

Reference yield:

N-(5-Acetylamino-2-methyl-phenyl)-2,2,2-trifluoro-acetamide → 2-amino-4-acetylaminotoluene (6375-16-2)

Guidance literature:

In methanol;

Reference yield:

4-Methyl-3-nitroanilin (119-32-4) → 2-amino-4-acetylaminotoluene (6375-16-2)

Guidance literature:

Multi-step reaction with 2 steps

2: iron; glacial acetic acid; water

With water; iron; acetic acid;

DOI:10.1111/j.1475-5890.2001.tb00037.x

upstream raw materials:

acetamide

4-methylbenzene-1,3-diamine

4-acetylamino-2-nitrotoluene

acetic acid

Downstream raw materials:

4-Acetylamino-2-vinylsulfamido-toluol

flubendiamide

6-methyl-N-(pyrimidin-2-yl)benzene-1,3-diamine hydrochloride

1-amino-4-(5'-amino-2'-methylphenylamino)-anthraquinone-2-sulphonic acid