((4S,6S)-6-(2-(tert-butyldiphenylsilyloxy)ethyl)-2,2-dimethyl-1,3-dioxan-4-yl)methanol

Base Information

Chemical Name:((4S,6S)-6-(2-(tert-butyldiphenylsilyloxy)ethyl)-2,2-dimethyl-1,3-dioxan-4-yl)methanol
CAS No.:214345-66-1
Molecular Formula:C₂₅H₃₆O₄Si
Molecular Weight:428.644
Hs Code.:

Synonyms:((4S,6S)-6-(2-(tert-butyldiphenylsilyloxy)ethyl)-2,2-dimethyl-1,3-dioxan-4-yl)methanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ((4S,6S)-6-(2-(tert-butyldiphenylsilyloxy)ethyl)-2,2-dimethyl-1,3-dioxan-4-yl)methanol

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Technology Process of ((4S,6S)-6-(2-(tert-butyldiphenylsilyloxy)ethyl)-2,2-dimethyl-1,3-dioxan-4-yl)methanol

There total 15 articles about ((4S,6S)-6-(2-(tert-butyldiphenylsilyloxy)ethyl)-2,2-dimethyl-1,3-dioxan-4-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 112497-22-0
(3S,5S)-6-<(benzyloxy)methyl>-4-<1-(tert-butyldiphenylsilyloxy)ethyl>-2,2-dimethyl-1,3-dioxacyclohexane

: 214345-66-1
((4S,6S)-6-(2-(tert-butyldiphenylsilyloxy)ethyl)-2,2-dimethyl-1,3-dioxan-4-yl)methanol

Guidance literature:: With hydrogen; palladium dihydroxide; In ethyl acetate; at 20 ℃; for 96h;
DOI:10.1016/j.tetlet.2008.07.022

Reference yield:

: 112497-21-9
(4S,6S)-6-<(benzyloxy)methyl>-4-(2-hydroxyethyl)-2,2-dimethyl-1,3-dioxacyclohexane

: 214345-66-1
((4S,6S)-6-(2-(tert-butyldiphenylsilyloxy)ethyl)-2,2-dimethyl-1,3-dioxan-4-yl)methanol

Guidance literature:: Multi-step reaction with 2 steps

1: imidazole / dimethylformamide

2: H₂ / Pd/C / aq. ethanol

With 1H-imidazole; hydrogen; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(01)80992-8

Reference yield:

: 112497-20-8
(4S,6R)-4-Benzyloxymethyl-2,2-dimethyl-6-vinyl-[1,3]dioxane

: 214345-66-1
((4S,6S)-6-(2-(tert-butyldiphenylsilyloxy)ethyl)-2,2-dimethyl-1,3-dioxan-4-yl)methanol

Guidance literature:: Multi-step reaction with 3 steps

1: 1) 9-BBN, 2) H₂O₂, NaOH / 1) THF, 25 deg C

2: imidazole / dimethylformamide

3: H₂ / Pd/C / aq. ethanol

With 1H-imidazole; sodium hydroxide; 9-borabicyclo[3.3.1]nonane dimer; hydrogen; dihydrogen peroxide; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(01)80992-8