Technology Process of (4S,6R)-4-Benzyloxymethyl-2,2-dimethyl-6-vinyl-[1,3]dioxane
There total 13 articles about (4S,6R)-4-Benzyloxymethyl-2,2-dimethyl-6-vinyl-[1,3]dioxane which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 13 steps
2: 70 percent / DIBAL, ZnCl2 / tetrahydrofuran / -78 °C
3: 95 percent / t-BuBr / CHCl3 / Heating
4: 1) Et3O(+)*BF4(-), 2) aq. K2CO3 / 1) CH2Cl2
5: 87 percent / tetrahydrofuran / -30 °C
6: imidazole / dimethylformamide
7: MeI, CaCO3 / acetonitrile; H2O
8: 70 percent / tetrahydrofuran / -78 °C
9: HF / acetonitrile; H2O
10: CSA / CH2Cl2
11: 75 percent / Ce(NH4)2(NO3)6 / acetonitrile; H2O
12: 80 percent / K2CO3 / methanol
13: 80 percent / n-BuLi / tetrahydrofuran / -78 °C
With
1H-imidazole; n-butyllithium; ammonium cerium(IV) nitrate; t-butyl bromide; camphor-10-sulfonic acid; hydrogen fluoride; triethyloxonium fluoroborate; diisobutylaluminium hydride; potassium carbonate; calcium carbonate; zinc(II) chloride; methyl iodide;
In
tetrahydrofuran; methanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/S0040-4039(01)80992-8
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 87 percent / tetrahydrofuran / -30 °C
2: imidazole / dimethylformamide
3: MeI, CaCO3 / acetonitrile; H2O
4: 70 percent / tetrahydrofuran / -78 °C
5: HF / acetonitrile; H2O
6: CSA / CH2Cl2
7: 75 percent / Ce(NH4)2(NO3)6 / acetonitrile; H2O
8: 80 percent / K2CO3 / methanol
9: 80 percent / n-BuLi / tetrahydrofuran / -78 °C
With
1H-imidazole; n-butyllithium; ammonium cerium(IV) nitrate; camphor-10-sulfonic acid; hydrogen fluoride; potassium carbonate; calcium carbonate; methyl iodide;
In
tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/S0040-4039(01)80992-8
