Methoxypiperamide

Base Information

• Chemical Name: Methoxypiperamide
• CAS No.: 67023-02-3
• Molecular Formula: C₁₃H₁₈N₂O₂
• Molecular Weight: 234.298
• UNII: QD2GQ3VGF4
• DSSTox Substance ID: DTXSID501032899
• Wikipedia: Methoxypiperamide
• Mol file: 67023-02-3.mol

Synonyms:Meop;Mexp;METHOXYPIPERAMIDE;QD2GQ3VGF4;UNII-QD2GQ3VGF4;67023-02-3;Piperazine, 1-(4-methoxybenzoyl)-4-methyl-;Methanone, (4-methoxyphenyl)(4-methyl-1-piperazinyl)-;BAS 03215882;Oprea1_462004;Oprea1_820066;(4-methoxyphenyl)(4-methylpiperazin-1-yl)methanone;SCHEMBL10053023;DTXSID501032899;STK408103;AKOS000640581;1-(4-methoxybenzoyl)-4-methylpiperazine;(4-METHOXYPHENYL)(4-METHYLPIPERAZINO)METHANONE;Z31434076

Chemical Property of Methoxypiperamide

Chemical Property:

• XLogP3: 0.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 234.136827821
• Heavy Atom Count: 17
• Complexity: 254

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CN1CCN(CC1)C(=O)C2=CC=C(C=C2)OC

Technology Process of Methoxypiperamide

There total 3 articles about Methoxypiperamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

1-methyl-piperazine (109-01-3) + carbon monoxide (201230-82-2) + para-iodoanisole (696-62-8) → 1-(4-methoxyphenyl)-2-(4-methylpiperazin-1-yl)ethane-1,2-dione + (4-methoxyphenyl)(4-methylpiperazin-1-yl)methanone methoxypiperamide (67023-02-3)

Guidance literature:

para-iodoanisole; With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 2h; Inert atmosphere;

1-methyl-piperazine; carbon monoxide; In N,N-dimethyl-formamide; at 80 ℃; for 24h; chemoselective reaction;

DOI:10.1039/c4gc02469a

Reference yield:

1-methyl-piperazine (109-01-3) + 1-bromo-4-methoxy-benzene (104-92-7) + carbon monoxide (201230-82-2) → 1-(4-methoxyphenyl)-2-(4-methylpiperazin-1-yl)ethane-1,2-dione + (4-methoxyphenyl)(4-methylpiperazin-1-yl)methanone methoxypiperamide (67023-02-3)

Guidance literature:

With potassium carbonate; 1,1'-bis(diphenylphosphino)ferrocene; [(Pd(μ-Cl)(κ(2)-P,C-P(OC6H2-2,4-tBu2)(OC6H3-2,4-tBu2)2))2]; In 1,4-dioxane; at 130 ℃; for 14h; under 6750.54 Torr;

DOI:10.1039/b615874a

Reference yield:

1-methyl-piperazine (109-01-3) + 4-methoxy-benzoyl chloride (100-07-2) → (4-methoxyphenyl)(4-methylpiperazin-1-yl)methanone methoxypiperamide (67023-02-3)

Guidance literature:

With sodium hydroxide; In dichloromethane; for 5h; Ambient temperature;

DOI:10.1021/jo00369a002

upstream raw materials:

1-methyl-piperazine

4-methoxy-benzoyl chloride

1-bromo-4-methoxy-benzene

carbon monoxide

Downstream raw materials:

1-(4-methoxy-2-methylbenzoyl)-4-methylpiperazine

4-methoxy-2-methylbenzoic acid

methyl 4-methoxy-2-methylbenzoate