N-(2-acetamidophenyl)-3-fluoro-5-[(2-fluoro-4-iodophenyl)amino]isonicotinamide

Base Information

Chemical Name:N-(2-acetamidophenyl)-3-fluoro-5-[(2-fluoro-4-iodophenyl)amino]isonicotinamide
CAS No.:1373870-90-6
Molecular Formula:C₂₀H₁₅F₂IN₄O₂
Molecular Weight:508.266
Hs Code.:

Synonyms:N-(2-acetamidophenyl)-3-fluoro-5-[(2-fluoro-4-iodophenyl)amino]isonicotinamide

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Chemical Property of N-(2-acetamidophenyl)-3-fluoro-5-[(2-fluoro-4-iodophenyl)amino]isonicotinamide

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Technology Process of N-(2-acetamidophenyl)-3-fluoro-5-[(2-fluoro-4-iodophenyl)amino]isonicotinamide

There total 3 articles about N-(2-acetamidophenyl)-3-fluoro-5-[(2-fluoro-4-iodophenyl)amino]isonicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 19.0%

: 1373870-89-3
N-(2-aminophenyl)-3-fluoro-5-[(2-fluoro-4-iodophenyl)amino]isonicotinamide

: 141-78-6
ethyl acetate

: 1373870-90-6
N-(2-acetamidophenyl)-3-fluoro-5-[(2-fluoro-4-iodophenyl)amino]isonicotinamide

Guidance literature:: N-(2-aminophenyl)-3-fluoro-5-[(2-fluoro-4-iodophenyl)amino]isonicotinamide; With 1,1,1,3,3,3-hexamethyl-disilazane; In tetrahydrofuran; at 20 ℃; for 18h; Inert atmosphere;

ethyl acetate; With hydrogenchloride; In tetrahydrofuran; water;

Reference yield:

: 29632-74-4
2-fluro-4-iodoaniline

: 1373870-90-6
N-(2-acetamidophenyl)-3-fluoro-5-[(2-fluoro-4-iodophenyl)amino]isonicotinamide

Guidance literature:: Multi-step reaction with 3 steps

1: lithium hexamethyldisilazane / tetrahydrofuran / 18 h / 3 - 20 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 18 h / 50 °C

3: 1,1,1,3,3,3-hexamethyl-disilazane / tetrahydrofuran / 18 h / 20 °C / Inert atmosphere

With N-ethyl-N,N-diisopropylamine; 1,1,1,3,3,3-hexamethyl-disilazane; HATU; lithium hexamethyldisilazane; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 903522-29-2
3,5-difluoro-4-pyridinecarboxylic acid

: 1373870-90-6
N-(2-acetamidophenyl)-3-fluoro-5-[(2-fluoro-4-iodophenyl)amino]isonicotinamide

Guidance literature:: Multi-step reaction with 3 steps

1: lithium hexamethyldisilazane / tetrahydrofuran / 18 h / 3 - 20 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 18 h / 50 °C

3: 1,1,1,3,3,3-hexamethyl-disilazane / tetrahydrofuran / 18 h / 20 °C / Inert atmosphere

With N-ethyl-N,N-diisopropylamine; 1,1,1,3,3,3-hexamethyl-disilazane; HATU; lithium hexamethyldisilazane; In tetrahydrofuran; N,N-dimethyl-formamide;