6-isopropyl-2-[2-n-propoxy-5-(4-methyl-piperazin-1-yl-sulfonyl)phenyl]pyrimid-4(3H)-one

Base Information

Chemical Name:6-isopropyl-2-[2-n-propoxy-5-(4-methyl-piperazin-1-yl-sulfonyl)phenyl]pyrimid-4(3H)-one
CAS No.:1229016-98-1
Molecular Formula:C₂₁H₃₀N₄O₄S
Molecular Weight:434.56
Hs Code.:

Synonyms:6-isopropyl-2-[2-n-propoxy-5-(4-methyl-piperazin-1-yl-sulfonyl)phenyl]pyrimid-4(3H)-one

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Chemical Property of 6-isopropyl-2-[2-n-propoxy-5-(4-methyl-piperazin-1-yl-sulfonyl)phenyl]pyrimid-4(3H)-one

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Technology Process of 6-isopropyl-2-[2-n-propoxy-5-(4-methyl-piperazin-1-yl-sulfonyl)phenyl]pyrimid-4(3H)-one

There total 5 articles about 6-isopropyl-2-[2-n-propoxy-5-(4-methyl-piperazin-1-yl-sulfonyl)phenyl]pyrimid-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1229019-36-6
5-(4-methylpiperazin-1-ylsulfonyl)-2-propoxybenzimidamide

: 7152-15-0
ethyl 4-methyl-3-oxo-pentanoate

: 1229016-98-1
6-isopropyl-2-[2-n-propoxy-5-(4-methyl-piperazin-1-yl-sulfonyl)phenyl]pyrimid-4(3H)-one

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 4h;
DOI:10.1021/jm301159y

Reference yield:

: 6609-58-1
2-propoxybenzonitrile

: 1229016-98-1
6-isopropyl-2-[2-n-propoxy-5-(4-methyl-piperazin-1-yl-sulfonyl)phenyl]pyrimid-4(3H)-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: chlorosulfonic acid / 24 h / 20 °C / Cooling with ice

2.1: dichloromethane / 0.5 h / Cooling with ice

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 18 h / 20 °C / Cooling with ice

3.2: pH 2 - 3

4.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 90 °C

With chlorosulfonic acid; potassium carbonate; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1229019-31-1
2-propoxy-5-(4-methylpiperazin-1-yl)sulphonylbenzonitrile

: 1229016-98-1
6-isopropyl-2-[2-n-propoxy-5-(4-methyl-piperazin-1-yl-sulfonyl)phenyl]pyrimid-4(3H)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 18 h / 20 °C / Cooling with ice

1.2: pH 2 - 3

2.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 90 °C

With potassium carbonate; lithium hexamethyldisilazane; In tetrahydrofuran; N,N-dimethyl-formamide;