(R)-4-(4-((4'-chlorobiphenyl-2-yl)(cyano)methyl)piperidin-1-yl)benzoic acid, hydrochloride salt

Base Information

Chemical Name:(R)-4-(4-((4'-chlorobiphenyl-2-yl)(cyano)methyl)piperidin-1-yl)benzoic acid, hydrochloride salt
CAS No.:1357577-15-1
Molecular Formula:C₂₆H₂₃ClN₂O₂*ClH
Molecular Weight:467.395
Hs Code.:

Synonyms:(R)-4-(4-((4'-chlorobiphenyl-2-yl)(cyano)methyl)piperidin-1-yl)benzoic acid, hydrochloride salt

Suppliers and Price of (R)-4-(4-((4'-chlorobiphenyl-2-yl)(cyano)methyl)piperidin-1-yl)benzoic acid, hydrochloride salt

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (R)-4-(4-((4'-chlorobiphenyl-2-yl)(cyano)methyl)piperidin-1-yl)benzoic acid, hydrochloride salt

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (R)-4-(4-((4'-chlorobiphenyl-2-yl)(cyano)methyl)piperidin-1-yl)benzoic acid, hydrochloride salt

There total 7 articles about (R)-4-(4-((4'-chlorobiphenyl-2-yl)(cyano)methyl)piperidin-1-yl)benzoic acid, hydrochloride salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4-(4-((4'-chlorobiphenyl-2-yl)(cyano)methyl)piperidin-1-yl)benzoic acid trifluoroacetate

: 1357577-15-1
(R)-4-(4-((4'-chlorobiphenyl-2-yl)(cyano)methyl)piperidin-1-yl)benzoic acid, hydrochloride salt

Guidance literature:: With hydrogenchloride; In methanol; diethyl ether; dichloromethane; for 0.166667h;

Reference yield:

: 19472-74-3
2-(2-bromophenyl)acetonitrile

: 1357577-15-1
(R)-4-(4-((4'-chlorobiphenyl-2-yl)(cyano)methyl)piperidin-1-yl)benzoic acid, hydrochloride salt

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; water / Inert atmosphere; Reflux

2.1: N,N-dimethyl-formamide; mineral oil / 1 h / 18 - 25 °C

2.2: 38 h / 0 - 25 °C

3.1: trifluoroacetic acid / dichloromethane; methanol / 0.25 h / 18 - 25 °C

3.2: pH ~ 11

4.1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 80 h / 120 °C

5.1: dichloromethane; methanol / 0.5 h / 18 - 25 °C

6.1: hydrogenchloride / dichloromethane; diethyl ether; methanol / 0.17 h

With hydrogenchloride; sodium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; diethyl ether; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; mineral oil; 1.1: Suzuki Coupling;

Reference yield:

: 1679-18-1
4-Chlorophenylboronic acid

: 1357577-15-1
(R)-4-(4-((4'-chlorobiphenyl-2-yl)(cyano)methyl)piperidin-1-yl)benzoic acid, hydrochloride salt

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; water / Inert atmosphere; Reflux

2.1: N,N-dimethyl-formamide; mineral oil / 1 h / 18 - 25 °C

2.2: 38 h / 0 - 25 °C

3.1: trifluoroacetic acid / dichloromethane; methanol / 0.25 h / 18 - 25 °C

3.2: pH ~ 11

4.1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 80 h / 120 °C

5.1: dichloromethane; methanol / 0.5 h / 18 - 25 °C

6.1: hydrogenchloride / dichloromethane; diethyl ether; methanol / 0.17 h

With hydrogenchloride; sodium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; diethyl ether; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; mineral oil; 1.1: Suzuki Coupling;