(Z)-1,2-diphenylvinyl 4-chlorophenylisopropylcarbamate

Base Information

• Chemical Name: (Z)-1,2-diphenylvinyl 4-chlorophenylisopropylcarbamate
• CAS No.: 1350911-39-5
• Molecular Formula: C₂₄H₂₂ClNO₂
• Molecular Weight: 391.897
• Mol file: 1350911-39-5.mol

Synonyms:(Z)-1,2-diphenylvinyl 4-chlorophenylisopropylcarbamate

Chemical Property of (Z)-1,2-diphenylvinyl 4-chlorophenylisopropylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (Z)-1,2-diphenylvinyl 4-chlorophenylisopropylcarbamate

There total 3 articles about (Z)-1,2-diphenylvinyl 4-chlorophenylisopropylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

phenyl benzyl ketone (451-40-1) + (4-chlorophenyl)(1-methylethyl)carbamic chloride (55239-61-7) → (Z)-1,2-diphenylvinyl 4-chlorophenylisopropylcarbamate (1350911-39-5)

Guidance literature:

With sodium methylsulfinylmethanide; In dimethyl sulfoxide; at 20 ℃; for 15h; Inert atmosphere;

DOI:10.1021/ol2029355

Reference yield:

N-(4-chlorophenyl)-N-isopropylamine (770-40-1) → (Z)-1,2-diphenylvinyl 4-chlorophenylisopropylcarbamate (1350911-39-5)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / dichloromethane / 2 h / 20 °C / Inert atmosphere

2: sodium methylsulfinylmethanide / dimethyl sulfoxide / 15 h / 20 °C / Inert atmosphere

With pyridine; sodium methylsulfinylmethanide; In dichloromethane; dimethyl sulfoxide;

DOI:10.1021/ol2029355

Reference yield:

4-chloro-aniline (106-47-8) → (Z)-1,2-diphenylvinyl 4-chlorophenylisopropylcarbamate (1350911-39-5)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium tris(acetoxy)borohydride / acetic acid; 1,2-dichloro-ethane / 4 h / 20 °C / Inert atmosphere

2: pyridine / dichloromethane / 2 h / 20 °C / Inert atmosphere

3: sodium methylsulfinylmethanide / dimethyl sulfoxide / 15 h / 20 °C / Inert atmosphere

With pyridine; sodium tris(acetoxy)borohydride; sodium methylsulfinylmethanide; In dichloromethane; acetic acid; dimethyl sulfoxide; 1,2-dichloro-ethane;

DOI:10.1021/ol2029355

upstream raw materials:

phenyl benzyl ketone

(4-chlorophenyl)(1-methylethyl)carbamic chloride

N-(4-chlorophenyl)-N-isopropylamine

4-chloro-aniline

Downstream raw materials:

1-(4-chlorophenyl)-1,2-diphenylhexan-1-ol