2-Bromo-6-chlorobenzoic acid

Base Information

• Chemical Name: 2-Bromo-6-chlorobenzoic acid
• CAS No.: 93224-85-2
• Molecular Formula: C7H4BrClO2
• Molecular Weight: 235.465
• Hs Code.: 2916399090
• Mol file: 93224-85-2.mol

Synonyms:2-Bromo-6-chlorobenzoicacid;NSC 190301;2-bromo-6-chloro-benzoic acid;

Chemical Property of 2-Bromo-6-chlorobenzoic acid

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 148-150 °C
• Refractive Index: 1.621
• Boiling Point: 315.883 °C at 760 mmHg
• PKA: 1.62±0.10(Predicted)
• Flash Point: 144.841 °C
• PSA: 37.30000
• Density: 1.81 g/cm³
• LogP: 2.80070
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

2-Bromo-6-chlorobenzoic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,T
• Statements: 25-36/37/38
• Safety Statements: 26-45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Bromo-6-chlorobenzoic acid

There total 10 articles about 2-Bromo-6-chlorobenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-bromo-3-chlorobenzene (108-37-2) + carbon dioxide (124-38-9,18923-20-1) → 2-bromo-6-chlorobenzoic acid (93224-85-2)

Guidance literature:

1-bromo-3-chlorobenzene; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃;

carbon dioxide; In tetrahydrofuran; at -78 - 20 ℃; for 2h;

DOI:10.1021/ol8026957

Reference yield: 62.0%

carbon dioxide (124-38-9,18923-20-1) + 3-chloro-1,2-dibromobenzene (104514-49-0) → 2-bromo-6-chlorobenzoic acid (93224-85-2) + 2-bromo-3-chlorobenzoic acid (56961-26-3)

Guidance literature:

3-chloro-1,2-dibromobenzene; With isopropylmagnesium chloride; In tetrahydrofuran; at -40 ℃; for 2h;

carbon dioxide; With hydrogenchloride; In tetrahydrofuran; for 1h; Further stages.;

DOI:10.1055/s-2006-947362

Reference yield: 56.0%

ortho-chlorobenzoic acid (118-91-2) → 2-bromo-6-chlorobenzoic acid (93224-85-2)

Guidance literature:

ortho-chlorobenzoic acid; With (E)-N,N,N′,N′-tetramethylethene-1,2-diamine; sec.-butyllithium; In tetrahydrofuran; at -78 ℃; for 0.5h;

With 1,2-dibromo-1,1,2,2-tetrachloroethane; In tetrahydrofuran; at -78 - 0 ℃;

DOI:10.1081/SCC-200050946

upstream raw materials:

2-bromo-6-chlorotoluene

1-bromo-3-chlorobenzene

carbon dioxide

ortho-chlorobenzoic acid

Downstream raw materials:

2-(2-bromo-6-chlorophenyl)-4-(1-methylethyl)quinazoline

2-chloro-6-formyl-benzoic acid

1-bromo-3-chloro-2-(trifluoromethyl)benzene