1-acetyl-2-chloro-3-(ω-N-phenylpiperazinoacetyl)aminoindole

Base Information

• Chemical Name: 1-acetyl-2-chloro-3-(ω-N-phenylpiperazinoacetyl)aminoindole
• CAS No.: 131172-44-6
• Molecular Formula: C₂₂H₂₃ClN₄O₂*ClH
• Molecular Weight: 447.364
• Mol file: 131172-44-6.mol

Synonyms:1-acetyl-2-chloro-3-(ω-N-phenylpiperazinoacetyl)aminoindole

Chemical Property of 1-acetyl-2-chloro-3-(ω-N-phenylpiperazinoacetyl)aminoindole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-acetyl-2-chloro-3-(ω-N-phenylpiperazinoacetyl)aminoindole

There total 2 articles about 1-acetyl-2-chloro-3-(ω-N-phenylpiperazinoacetyl)aminoindole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

4-phenyl-1-piperazine (92-54-6) + 1-acetyl-2-chloro-3-(ω-chloroacetyl)aminoindole (131172-51-5) → 1-acetyl-2-chloro-3-(ω-N-phenylpiperazinoacetyl)aminoindole (131172-44-6)

Guidance literature:

In acetonitrile; at 20 ℃; for 24h;

DOI:10.1007/BF00487425

Reference yield:

1-acetyl-2-chloro-3-iminoindoline hydrochloride (123689-03-2) → 1-acetyl-2-chloro-3-(ω-N-phenylpiperazinoacetyl)aminoindole (131172-44-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / 0.08 h / Heating

2: 91 percent / acetonitrile / 24 h / 20 °C

In acetonitrile;

DOI:10.1007/BF00487425

upstream raw materials:

4-phenyl-1-piperazine

1-acetyl-2-chloro-3-(ω-chloroacetyl)aminoindole

1-acetyl-2-chloro-3-iminoindoline hydrochloride