Acetic acid (S)-2-[benzyl-((1S,2S)-2-dibenzylamino-1-ethyl-3-phenyl-propyl)-amino]-3-methyl-butyl ester

Base Information

• Chemical Name: Acetic acid (S)-2-[benzyl-((1S,2S)-2-dibenzylamino-1-ethyl-3-phenyl-propyl)-amino]-3-methyl-butyl ester
• CAS No.: 123054-02-4
• Molecular Formula: C₃₉H₄₈N₂O₂
• Molecular Weight: 576.822
• Mol file: 123054-02-4.mol

Synonyms:Acetic acid (S)-2-[benzyl-((1S,2S)-2-dibenzylamino-1-ethyl-3-phenyl-propyl)-amino]-3-methyl-butyl ester

Chemical Property of Acetic acid (S)-2-[benzyl-((1S,2S)-2-dibenzylamino-1-ethyl-3-phenyl-propyl)-amino]-3-methyl-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Acetic acid (S)-2-[benzyl-((1S,2S)-2-dibenzylamino-1-ethyl-3-phenyl-propyl)-amino]-3-methyl-butyl ester

There total 18 articles about Acetic acid (S)-2-[benzyl-((1S,2S)-2-dibenzylamino-1-ethyl-3-phenyl-propyl)-amino]-3-methyl-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

(1'S,2S,3S)-N2,N2,N3-tribenzyl-N3-<1'-(hydroxymethyl)-2'-methylpropyl>-1-phenyl-2,3-pentanediamine (123054-06-8) + acetyl chloride (75-36-5) → Acetic acid (S)-2-[benzyl-((1S,2S)-2-dibenzylamino-1-ethyl-3-phenyl-propyl)-amino]-3-methyl-butyl ester (123054-02-4)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 0 - 20 ℃; for 3h;

DOI:10.1021/jo00284a032

Reference yield:

(1'S,2S,3R)-N2,N2,N3-tribenzyl-N3-<1'-(hydroxymethyl)-2'-methylpropyl>-1-phenyl-2,3-pentanediamine (123122-68-9) + acetyl chloride (75-36-5) → Acetic acid (S)-2-[benzyl-((1R,2S)-2-dibenzylamino-1-ethyl-3-phenyl-propyl)-amino]-3-methyl-butyl ester (123054-02-4)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 0 - 20 ℃; for 3h;

DOI:10.1021/jo00284a032

Reference yield:

(1'S,2R,3R)-N2,N2,N3-tribenzyl-N3-<1'-(hydroxymethyl)-2'-methylpropyl>-1-phenyl-2,3-pentanediamine (123122-70-3) + acetyl chloride (75-36-5) → Acetic acid (S)-2-[benzyl-((1R,2R)-2-dibenzylamino-1-ethyl-3-phenyl-propyl)-amino]-3-methyl-butyl ester (123054-02-4)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 0 - 20 ℃; for 3h;

DOI:10.1021/jo00284a032

upstream raw materials:

(1'S,2S,3R)-N²,N²,N³-tribenzyl-N³-<1'-(hydroxymethyl)-2'-methylpropyl>-1-phenyl-2,3-pentanediamine

acetyl chloride

(S)-valinol

(2S)-N,N-dibenzylphenylalaninal

Downstream raw materials:

(1'S,4S,5S)-1-<1'-(acetoxymethyl)-2'-methylpropyl>-4-benzyl-5-ethyl-2-imidazolidone

Acetic acid (S)-2-((1S,2S)-2-amino-1-ethyl-3-phenyl-propylamino)-3-methyl-butyl ester

(1'S,2R,3R)-N²,N²,N³-tribenzyl-N³-<1'-(hydroxymethyl)-2'-methylpropyl>-1-phenyl-2,3-pentanediamine

Acetic acid (S)-2-((1R,2R)-2-amino-1-ethyl-3-phenyl-propylamino)-3-methyl-butyl ester