tert-butyl 4-<3-(2,4-diamino-7H-pyrrolo<2,3-d>pyrimidin-5-yl)-1-methylpropyl>benzoate

Base Information

Chemical Name:tert-butyl 4-<3-(2,4-diamino-7H-pyrrolo<2,3-d>pyrimidin-5-yl)-1-methylpropyl>benzoate
CAS No.:130377-73-0
Molecular Formula:C₂₁H₂₇N₅O₂
Molecular Weight:381.478
Hs Code.:

Synonyms:tert-butyl 4-<3-(2,4-diamino-7H-pyrrolo<2,3-d>pyrimidin-5-yl)-1-methylpropyl>benzoate

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Chemical Property of tert-butyl 4-<3-(2,4-diamino-7H-pyrrolo<2,3-d>pyrimidin-5-yl)-1-methylpropyl>benzoate

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Technology Process of tert-butyl 4-<3-(2,4-diamino-7H-pyrrolo<2,3-d>pyrimidin-5-yl)-1-methylpropyl>benzoate

There total 7 articles about tert-butyl 4-<3-(2,4-diamino-7H-pyrrolo<2,3-d>pyrimidin-5-yl)-1-methylpropyl>benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 130377-72-9
tert-butyl 4-<3-(2,4-diamino-6-oxo-6,7-dihydro-5H-pyrrolo<2,3-d>pyrimidin-5-yl)-1-methylpropyl>benzoate

: 125991-61-9
tert-butyl 4-<3-(2,4-diamino-6,7-dihydro-5H-pyrrolo<2,3-d>pyrimidin-5-yl)-1-methylpropyl>benzoate

: 130377-73-0
tert-butyl 4-<3-(2,4-diamino-7H-pyrrolo<2,3-d>pyrimidin-5-yl)-1-methylpropyl>benzoate

Guidance literature:: With borane-THF; at 0 ℃; for 5h;
DOI:10.1021/jm00106a012

Reference yield:

: tert-butyl 4-[3-(2,4-diamino-6-hydroxy-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-1-methylpropyl]benzoate

: 112317-27-8
glacial acetic acid methyl alcohol

: 125991-61-9
tert-butyl 4-<3-(2,4-diamino-6,7-dihydro-5H-pyrrolo<2,3-d>pyrimidin-5-yl)-1-methylpropyl>benzoate

: 130377-73-0
tert-butyl 4-<3-(2,4-diamino-7H-pyrrolo<2,3-d>pyrimidin-5-yl)-1-methylpropyl>benzoate

Guidance literature:: With ammonia; In tetrahydrofuran;

Reference yield:

: 105580-41-4
4-acetylbenzoic acid tert-butyl ester

: 130377-73-0
tert-butyl 4-<3-(2,4-diamino-7H-pyrrolo<2,3-d>pyrimidin-5-yl)-1-methylpropyl>benzoate

Guidance literature:: Multi-step reaction with 6 steps

1: 85 percent / Zn, I₂ / benzene; diethyl ether; tetrahydrofuran / 1.25 h / Heating

2: 85 percent / H₂, acetic acid / 5percent Pd/C / ethanol / 115 h

3: 1.) LDA, 2.) I₂ / 1.) hexane, THF, -78 deg C, 10 min, 2.) a) -78 deg C, 20 min, b) from -78 deg C to 0 deg C, 30 min

4: 1.) NaH / 1.) Me₂SO, RT, 5 min, 2.) 20 deg C, 1 h

5: 79 percent / t-BuOK / 2-methyl-propan-2-ol / 4 h / Heating

6: 40 percent / BH₃-THF / 5 h / 0 °C

With borane-THF; potassium tert-butylate; hydrogen; iodine; sodium hydride; acetic acid; zinc; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; ethanol; tert-butyl alcohol; benzene;
DOI:10.1021/jm00106a012