130377-72-9

Upstream product

• 50-01-1 guanidine hydrochloride 
• 125991-47-1 ethyl 5-<4-(tert-butoxycarbonyl)phenyl>-2-(dicyanomethyl)hexanoate 
• 130351-30-3 ethyl 5-<4-(tert-butoxycarbonyl)phenyl>-5-hydroxy-2-hexenoate 
• 125991-46-0 ethyl 5-<4-(tert-butoxycarbonyl)phenyl>-2-iodohexanoate 
• 105580-41-4 4-acetylbenzoic acid tert-butyl ester 

Downstream Products

• 125991-63-1 diethyl N-<4-<3-(2,4-diamino-6,7-dihydro-5H-pyrrolo<2,3-d>pyrimidin-5-yl)-1-methylpropyl>benzoyl>-L-glutamate 
• 125991-65-3 diethyl N-<4-<3-(2,4-diamino-7H-pyrrolo<2,3-d>pyrimidin-5-yl)-1-methylpropyl>benzoyl>-L-glutamate 
• 125991-64-2 N-[4-[3-(2,4-diamino-6,7-dihydro-5H-pyrrolo[2,3-d]-pyrimidin-5-yl)-1-methylpropyl]benzoyl]-L-glutamic acid 
• 125991-66-4 N-<4-<3-(2,4-diamino-7H-pyrrolo<2,3-d>pyrimidin-5-yl)-1-methylpropyl>benzoyl>-L-glutamic acid 
• 125991-61-9 tert-butyl 4-<3-(2,4-diamino-6,7-dihydro-5H-pyrrolo<2,3-d>pyrimidin-5-yl)-1-methylpropyl>benzoate 
• 130377-73-0 tert-butyl 4-<3-(2,4-diamino-7H-pyrrolo<2,3-d>pyrimidin-5-yl)-1-methylpropyl>benzoate 

Relevant academic research and scientific papers

Novel Pyrrolopyrimidine Antifolates: Synthesis and Antitumor Activities

New antifolates, characterized by a 6-5 fused ring system, a pyrrolopyrimidine ring, and a trimethylene bridge at position 5 (12a,b and 13a,b) were designed and efficiently synthesized.The synthetic method included (1) construction of the key inter