(S)2-acetamido-N-(6-(4-(4-fluorophenoxy)phenyl)pyridin-2-yl)-4-methylpentanamide

Base Information

Chemical Name:(S)2-acetamido-N-(6-(4-(4-fluorophenoxy)phenyl)pyridin-2-yl)-4-methylpentanamide
CAS No.:1383708-61-9
Molecular Formula:C₂₅H₂₆FN₃O₃
Molecular Weight:435.498
Hs Code.:

Synonyms:(S)2-acetamido-N-(6-(4-(4-fluorophenoxy)phenyl)pyridin-2-yl)-4-methylpentanamide

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Chemical Property of (S)2-acetamido-N-(6-(4-(4-fluorophenoxy)phenyl)pyridin-2-yl)-4-methylpentanamide

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Technology Process of (S)2-acetamido-N-(6-(4-(4-fluorophenoxy)phenyl)pyridin-2-yl)-4-methylpentanamide

There total 3 articles about (S)2-acetamido-N-(6-(4-(4-fluorophenoxy)phenyl)pyridin-2-yl)-4-methylpentanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: 1188-21-2
N-Ac-Leu

: 1383709-50-9
6-(4-(4-fluorophenoxy)phenyl)pyridin-2-amine

: 1383708-61-9
(S)2-acetamido-N-(6-(4-(4-fluorophenoxy)phenyl)pyridin-2-yl)-4-methylpentanamide

Guidance literature:: N-Ac-Leu; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; for 1h;

6-(4-(4-fluorophenoxy)phenyl)pyridin-2-amine; In dichloromethane; at 20 ℃;

Reference yield:

: 19798-81-3,1184170-10-2
2-Amino-6-bromopyridine

: 1383708-61-9
(S)2-acetamido-N-(6-(4-(4-fluorophenoxy)phenyl)pyridin-2-yl)-4-methylpentanamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 4 h / Reflux

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 1 h

2.2: 20 °C

With sodium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1355052-34-4
2-(4-(4-fluorophenoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

: 1383708-61-9
(S)2-acetamido-N-(6-(4-(4-fluorophenoxy)phenyl)pyridin-2-yl)-4-methylpentanamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 4 h / Reflux

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 1 h

2.2: 20 °C

With sodium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane; water; N,N-dimethyl-formamide;