14-allyloxy-3-benzyloxy-17-cyclopropylmethyl-6-(1',3'-dioxolan-2'-yl)-4,5α-epoxymorphinan

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Chemical Name:14-allyloxy-3-benzyloxy-17-cyclopropylmethyl-6-(1',3'-dioxolan-2'-yl)-4,5α-epoxymorphinan
CAS No.:1192542-80-5
Molecular Formula:C₃₂H₃₇NO₅
Molecular Weight:515.649
Hs Code.:

Synonyms:14-allyloxy-3-benzyloxy-17-cyclopropylmethyl-6-(1',3'-dioxolan-2'-yl)-4,5α-epoxymorphinan

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Chemical Property of 14-allyloxy-3-benzyloxy-17-cyclopropylmethyl-6-(1',3'-dioxolan-2'-yl)-4,5α-epoxymorphinan

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Technology Process of 14-allyloxy-3-benzyloxy-17-cyclopropylmethyl-6-(1',3'-dioxolan-2'-yl)-4,5α-epoxymorphinan

There total 6 articles about 14-allyloxy-3-benzyloxy-17-cyclopropylmethyl-6-(1',3'-dioxolan-2'-yl)-4,5α-epoxymorphinan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 106-95-6
allyl bromide

: 547767-36-2
3-(benzyloxy)-17-(cyclopropylmethyl)-4,5α-epoxy-14β-hydroxymorphinan-6-one ethane-1,2-diyl acetal

: 1192542-80-5
14-allyloxy-3-benzyloxy-17-cyclopropylmethyl-6-(1',3'-dioxolan-2'-yl)-4,5α-epoxymorphinan

Guidance literature:: 3-(benzyloxy)-17-(cyclopropylmethyl)-4,5α-epoxy-14β-hydroxymorphinan-6-one ethane-1,2-diyl acetal; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 0.5h; Inert atmosphere;

allyl bromide; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; Product distribution / selectivity;

Reference yield:

: 100-39-0
benzyl bromide

: 1192542-80-5
14-allyloxy-3-benzyloxy-17-cyclopropylmethyl-6-(1',3'-dioxolan-2'-yl)-4,5α-epoxymorphinan

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide

2: toluene-4-sulfonic acid / toluene

3: sodium hydride / N,N-dimethyl-formamide

With sodium hydride; potassium carbonate; toluene-4-sulfonic acid; In N,N-dimethyl-formamide; toluene;
DOI:10.1186/s12929-021-00758-y

Reference yield:

: 153567-11-4
2,2,2-trichloroethyl (4'R,7a'R,12b'S)-9'-(benzyloxy)-1',2',4',6'-tetrahydro-3'H,7a'Hspiro[[1,3]dioxolane-2,7'-[4,12]methanobenzofuro[3,2-e]isoquinoline]-3'-carboxylate

: 1192542-80-5
14-allyloxy-3-benzyloxy-17-cyclopropylmethyl-6-(1',3'-dioxolan-2'-yl)-4,5α-epoxymorphinan

Guidance literature:: Multi-step reaction with 2 steps

1: toluene-4-sulfonic acid / toluene

2: sodium hydride / N,N-dimethyl-formamide

With sodium hydride; toluene-4-sulfonic acid; In N,N-dimethyl-formamide; toluene;
DOI:10.1186/s12929-021-00758-y