17-cyclopropylmethyl-3-benzyloxy-14-(2',3'-dihydroxypropyloxy)-6-(1',3'-dioxolan-2'-yl)-4,5α-epoxymorphinan

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Chemical Name:17-cyclopropylmethyl-3-benzyloxy-14-(2',3'-dihydroxypropyloxy)-6-(1',3'-dioxolan-2'-yl)-4,5α-epoxymorphinan
CAS No.:1192542-95-2
Molecular Formula:C₃₂H₃₉NO₇
Molecular Weight:549.664
Hs Code.:

Synonyms:17-cyclopropylmethyl-3-benzyloxy-14-(2',3'-dihydroxypropyloxy)-6-(1',3'-dioxolan-2'-yl)-4,5α-epoxymorphinan

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Chemical Property of 17-cyclopropylmethyl-3-benzyloxy-14-(2',3'-dihydroxypropyloxy)-6-(1',3'-dioxolan-2'-yl)-4,5α-epoxymorphinan

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Technology Process of 17-cyclopropylmethyl-3-benzyloxy-14-(2',3'-dihydroxypropyloxy)-6-(1',3'-dioxolan-2'-yl)-4,5α-epoxymorphinan

There total 4 articles about 17-cyclopropylmethyl-3-benzyloxy-14-(2',3'-dihydroxypropyloxy)-6-(1',3'-dioxolan-2'-yl)-4,5α-epoxymorphinan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 1192542-80-5
14-allyloxy-3-benzyloxy-17-cyclopropylmethyl-6-(1',3'-dioxolan-2'-yl)-4,5α-epoxymorphinan

: 1192542-95-2
17-cyclopropylmethyl-3-benzyloxy-14-(2',3'-dihydroxypropyloxy)-6-(1',3'-dioxolan-2'-yl)-4,5α-epoxymorphinan

Guidance literature:: 14-allyloxy-3-benzyloxy-17-cyclopropylmethyl-6-(1',3'-dioxolan-2'-yl)-4,5α-epoxymorphinan; osmium(VIII) oxide; In water; acetone; tert-butyl alcohol; at 20 ℃; for 0.166667h;

With 4-methylmorpholine N-oxide; In water; acetone; tert-butyl alcohol; at 20 ℃; for 24h;

Reference yield:

: 16676-29-2
naltrexone Hydrochloride

: 1192542-95-2
17-cyclopropylmethyl-3-benzyloxy-14-(2',3'-dihydroxypropyloxy)-6-(1',3'-dioxolan-2'-yl)-4,5α-epoxymorphinan

Guidance literature:: Multi-step reaction with 4 steps

1.1: methanesulfonic acid / 3 h / 90 - 100 °C

1.2: pH 10

2.1: potassium carbonate / N,N-dimethyl-formamide / 20 h / 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C / Inert atmosphere

3.2: 20 °C

4.1: osmium(VIII) oxide / water; acetone; tert-butyl alcohol / 0.17 h / 20 °C

4.2: 24 h / 20 °C

With methanesulfonic acid; sodium hydride; potassium carbonate; osmium(VIII) oxide; In water; N,N-dimethyl-formamide; acetone; mineral oil; tert-butyl alcohol;

Reference yield:

: 16676-32-7
(4'R,4a'S,7a'R,12b'S)-3'-(cyclopropylmethyl)-1',2',3',4',5',6'-hexahydro-4a'H,7a'H-spiro[[1,3]dioxolane-2,7'-[4,12]methanobenzofuro[3,2-e]isoquinoline]-4a',9'-diol

: 1192542-95-2
17-cyclopropylmethyl-3-benzyloxy-14-(2',3'-dihydroxypropyloxy)-6-(1',3'-dioxolan-2'-yl)-4,5α-epoxymorphinan

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 20 h / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C / Inert atmosphere

2.2: 20 °C

3.1: osmium(VIII) oxide / water; acetone; tert-butyl alcohol / 0.17 h / 20 °C

3.2: 24 h / 20 °C

With sodium hydride; potassium carbonate; osmium(VIII) oxide; In water; N,N-dimethyl-formamide; acetone; mineral oil; tert-butyl alcohol;