Technology Process of 1-[3-chloro-5-(trifluoromethyl)phenyl]-N-methylethanamine
There total 6 articles about 1-[3-chloro-5-(trifluoromethyl)phenyl]-N-methylethanamine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
3'-chloro 5'-(trifluoromethyl)acetophenone; methylamine;
In
methanol;
at 20 ℃;
for 48h;
With
sodium tetrahydroborate;
In
methanol;
at 0 - 20 ℃;
for 2h;
With
sodium hydroxide; water;
In
methanol;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sulfuric acid; nitric acid / 4 h / 0 - 35 °C
2.1: hydrogen / palladium 10% on activated carbon / ethanol / 7 h / 20 °C / 760.05 Torr
3.1: tert.-butylnitrite; copper(l) chloride / acetonitrile / 0.5 h / 45 - 50 °C
3.2: 0.17 h / 10 °C
4.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / acetonitrile / 14 h / 20 °C
5.1: tetrahydrofuran / 2 h / -30 - 20 °C
6.1: methanol / 48 h / 20 °C
6.2: 2 h / 0 - 20 °C
With
tert.-butylnitrite; sulfuric acid; hydrogen; nitric acid; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; copper(l) chloride;
palladium 10% on activated carbon;
In
tetrahydrofuran; methanol; ethanol; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: hydrogen / palladium 10% on activated carbon / ethanol / 7 h / 20 °C / 760.05 Torr
2.1: tert.-butylnitrite; copper(l) chloride / acetonitrile / 0.5 h / 45 - 50 °C
2.2: 0.17 h / 10 °C
3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / acetonitrile / 14 h / 20 °C
4.1: tetrahydrofuran / 2 h / -30 - 20 °C
5.1: methanol / 48 h / 20 °C
5.2: 2 h / 0 - 20 °C
With
tert.-butylnitrite; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; copper(l) chloride;
palladium 10% on activated carbon;
In
tetrahydrofuran; methanol; ethanol; acetonitrile;
