2-(4-fluorophenyl)-6-(N-(2-hydroxyethyl)methylsulfonamido)-N-methyl-5-(3-(1-(pyridin-2-yl)cyclopropylcarbamoyl)phenyl)benzofuran-3-carboxamide

Base Information

Chemical Name:2-(4-fluorophenyl)-6-(N-(2-hydroxyethyl)methylsulfonamido)-N-methyl-5-(3-(1-(pyridin-2-yl)cyclopropylcarbamoyl)phenyl)benzofuran-3-carboxamide
CAS No.:1217336-96-3
Molecular Formula:C₃₄H₃₁FN₄O₆S
Molecular Weight:642.708
Hs Code.:

2-(4-fluorophenyl)-6-(N-(2-hydroxyethyl)methylsulfonamido)-N-methyl-5-(3-(1-(pyridin-2-yl)cyclopropylcarbamoyl)phenyl)benzofuran-3-carboxamide

Synonyms:2-(4-fluorophenyl)-6-(N-(2-hydroxyethyl)methylsulfonamido)-N-methyl-5-(3-(1-(pyridin-2-yl)cyclopropylcarbamoyl)phenyl)benzofuran-3-carboxamide

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Chemical Property of 2-(4-fluorophenyl)-6-(N-(2-hydroxyethyl)methylsulfonamido)-N-methyl-5-(3-(1-(pyridin-2-yl)cyclopropylcarbamoyl)phenyl)benzofuran-3-carboxamide

Chemical Property:

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Technology Process of 2-(4-fluorophenyl)-6-(N-(2-hydroxyethyl)methylsulfonamido)-N-methyl-5-(3-(1-(pyridin-2-yl)cyclopropylcarbamoyl)phenyl)benzofuran-3-carboxamide

There total 13 articles about 2-(4-fluorophenyl)-6-(N-(2-hydroxyethyl)methylsulfonamido)-N-methyl-5-(3-(1-(pyridin-2-yl)cyclopropylcarbamoyl)phenyl)benzofuran-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

: 437985-36-9
1-(pyridin-2-yl)cyclopropan-1-amine dihydrochloride

: 1217339-23-5
3-(2-(4-fluorophenyl)-6-(N-(2-hydroxyethyl)methylsulfonamido)-3-(methylcarbamoyl)benzofuran-5-yl)benzoic acid

: 1217336-96-3
2-(4-fluorophenyl)-6-(N-(2-hydroxyethyl)methylsulfonamido)-N-methyl-5-(3-(1-(pyridin-2-yl)cyclopropylcarbamoyl)phenyl)benzofuran-3-carboxamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

Reference yield:

: 691857-46-2
ethyl 2-(4-fluorophenyl)-5-hydroxy-6-nitrobenzofuran-3-carboxylate

: 1217336-96-3
2-(4-fluorophenyl)-6-(N-(2-hydroxyethyl)methylsulfonamido)-N-methyl-5-(3-(1-(pyridin-2-yl)cyclopropylcarbamoyl)phenyl)benzofuran-3-carboxamide

Guidance literature:: Multi-step reaction with 11 steps

1: sodium hydroxide; water / ethanol; tetrahydrofuran / 64 °C

2: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1 h / 0 - 20 °C

3: sodium hydroxide; water / ethanol / 70 °C

4: triethylamine / dichloromethane / 23 h / 0 - 20 °C / Inert atmosphere

5: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 90 °C

6: acetic acid; iron / ethanol / 1 h / 90 °C

7: pyridine / 20 - 25 °C

8: sodium carbonate / N,N-dimethyl-formamide / 20 - 100 °C

9: sodium hydroxide; water / ethanol / 4 h / 60 °C

10: hydrogenchloride / tetrahydrofuran / 1 h

11: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 1 h / 20 °C

With pyridine; hydrogenchloride; water; iron; sodium carbonate; caesium carbonate; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 691856-86-7
ethyl 2-(4-fluorophenyl)-5-hydroxybenzofuran-3-carboxylate

: 1217336-96-3
2-(4-fluorophenyl)-6-(N-(2-hydroxyethyl)methylsulfonamido)-N-methyl-5-(3-(1-(pyridin-2-yl)cyclopropylcarbamoyl)phenyl)benzofuran-3-carboxamide

Guidance literature:: Multi-step reaction with 12 steps

1: nitric acid / chloroform / 0.17 h / 20 °C

2: sodium hydroxide; water / ethanol; tetrahydrofuran / 64 °C

3: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1 h / 0 - 20 °C

4: sodium hydroxide; water / ethanol / 70 °C

5: triethylamine / dichloromethane / 23 h / 0 - 20 °C / Inert atmosphere

6: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 90 °C

7: acetic acid; iron / ethanol / 1 h / 90 °C

8: pyridine / 20 - 25 °C

9: sodium carbonate / N,N-dimethyl-formamide / 20 - 100 °C

10: sodium hydroxide; water / ethanol / 4 h / 60 °C

11: hydrogenchloride / tetrahydrofuran / 1 h

12: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 1 h / 20 °C

With pyridine; hydrogenchloride; water; nitric acid; iron; sodium carbonate; caesium carbonate; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide;